JAHA:经皮冠状动脉介入术后急性心肌梗死患者血管扩张型β受体阻滞剂的效果分析!

2017-10-26 xing.T MedSci原创

血管扩张型β受体阻滞剂治疗在现代再灌注时代对急性心肌梗死患者的临床疗效优于常规β受体阻滞剂治疗。血管扩张型β受体阻滞剂可以被优先推荐用于急性心肌梗死患者。

尽管目前的指南推荐了急性心肌梗死(MI)后使用β受体阻滞剂,但是在现代再灌注时代β受体阻滞剂的作用尚未得到很好的研究。具体而言,血管扩张的β阻滞剂与传统β受体阻滞剂相关的益处尚未得到证实,近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。


研究人员使用全国多中心急性心肌梗死登记资料,分析了7127例急性心肌梗死患者经支架成功经皮冠状动脉介入治疗并服用β受体阻滞剂:血管扩张型β受体阻滞剂(n=3482)和常规β受体阻断剂(n=3645)的临床疗效。在整个人群中,血管扩张性β受体阻滞剂组1年内心脏死亡发生率显著降低(血管扩张型β受体阻滞剂与常规β受体阻滞剂相比,1.0% vs. 1.9%,P=0.003)。在2882对倾向得分匹配的人群中,血管扩张型β受体阻滞剂组受试者心脏死亡的发生率显著降低(1.1% vs. 1.8%; P=0.028)。虽然心肌梗死(1.1%vs. 1.5%; P=0.277)、血运重建(2.8% vs. 3.0%; P=0.791)和心力衰竭住院(1.4% vs. 1.9%; P=0.210)的发生率两组之间没有差异,血管扩张型β受体阻滞剂组心源性死亡或MI(2.0% vs. 3.1%; P=0.010)、心脏死亡、MI或心力衰竭住院(3.0% vs. 4.5%; P=0.003)和心源性死亡、MI、血运重建(3.9% vs. 5.3%; P=0.026)以及心源性死亡、MI、血管重建或心力衰竭住院治疗(4.8% vs. 6.5%; P=0.011)均显著降低。

由此可见,血管扩张型β受体阻滞剂治疗在现代再灌注时代对急性心肌梗死患者的临床疗效优于常规β受体阻滞剂治疗。血管扩张型β受体阻滞剂可以被优先推荐用于急性心肌梗死患者。

原始出处:

Jaehoon Chung,et al.Benefit of Vasodilating β‐Blockers in Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention: Nationwide Multicenter Cohort Study.JAHA.2017. https://doi.org/10.1161/JAHA.117.007063 


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    2017-12-20 lsj637
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  5. 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time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256172, encodeId=c1f52561e27c, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Oct 26 18:15:40 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-11-25 zhyy88
  6. 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  8. 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    2017-10-28 zhaohui6731
  9. 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time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256172, encodeId=c1f52561e27c, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Oct 26 18:15:40 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-26 changjiu

    学习了.谢谢

    0

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