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Life Sci：多种不同类型的植物雌激素可改善双酚A刺激的成骨细胞的骨矿化

2018-11-09 MedSci MedSci原创

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植物雌激素和异雌激素在骨形成和分化中充当激动剂/拮抗剂。强骨骼取决于成骨细胞形成新组织和使新形成的组织矿化的能力。功能失调或矿化损失导致骨骼脆弱和骨折风险的增加。在这项研究中，我们报道了不同类型的植物雌激素（大豆苷元，染料木黄酮和牛尿酚素）对双酚A（BPA）刺激的hFOB 1.19细胞矿化的影响。 通过评估钙，磷酸盐含量和碱性磷酸酶活性来研究植物雌激素的细胞矿化能力。此外，还测量了骨相关标记

植物雌激素和异雌激素在骨形成和分化中充当激动剂/拮抗剂。强骨骼取决于成骨细胞形成新组织和使新形成的组织矿化的能力。功能失调或矿化损失导致骨骼脆弱和骨折风险的增加。在这项研究中，我们报道了不同类型的植物雌激素（大豆苷元，染料木黄酮和牛尿酚素）对双酚A（BPA）刺激的hFOB 1.19细胞矿化的影响。

通过评估钙，磷酸盐含量和碱性磷酸酶活性来研究植物雌激素的细胞矿化能力。此外，还测量了骨相关标记物，骨钙蛋白和骨粘连蛋白的表达。

结果显示，BPA明显干扰hFOB1.19细胞中的骨矿化。然而，与未处理的BPA组相比，大豆苷元和染料木黄酮（特别是在5和40μg/mL的剂量下）的矿化效果增加更加明显，正如钙和磷酸盐含量跟高以及ALP活性更强所示。通过形态学发现证实了定量分析。植物雌激素处理的细胞中骨钙素和骨粘连蛋白水平增加。这些发现揭示了植物雌激素在hFOB 1.19细胞中由于BPA暴露而恢复脱矿质过程的潜在影响。

综上所述，该研究发现在BPA暴露下用植物雌激素处理后维持成骨细胞分化和矿化。

原始出处：

Thent ZC, Froemming GRA, et al., Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblast. Life Sci. 2018 Oct 1;210:214-223. doi: 10.1016/j.lfs.2018.08.057. Epub 2018 Aug 24.

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    2019-09-22 yahu

    #矿化#

    0

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    2019-03-25 一叶知秋

    #不同类型#

    0

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    2018-11-19 xuyong535

    #植物#

    0

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    2019-03-09 clmlylxy

    #Life#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1721318, encodeId=0f7d1e2131861, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Sun Sep 22 11:01:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068826, encodeId=8dad2068826f3, content=<a href='/topic/show?id=9da3203482c' target=_blank style='color:#2F92EE;'>#不同类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20348, encryptionId=9da3203482c, topicName=不同类型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Mar 25 07:01:00 CST 2019, time=2019-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745303, encodeId=ec911e4530369, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Mon Nov 19 02:01:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068577, encodeId=4ca120685e766, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sat Mar 09 13:01:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350110, encodeId=b659135011097, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351898, encodeId=2250135189814, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495101, encodeId=6979149510189, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-11 zhaojie88

    #双酚A#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1721318, encodeId=0f7d1e2131861, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Sun Sep 22 11:01:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068826, encodeId=8dad2068826f3, content=<a href='/topic/show?id=9da3203482c' target=_blank style='color:#2F92EE;'>#不同类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20348, encryptionId=9da3203482c, topicName=不同类型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Mar 25 07:01:00 CST 2019, time=2019-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745303, encodeId=ec911e4530369, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Mon Nov 19 02:01:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068577, encodeId=4ca120685e766, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sat Mar 09 13:01:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350110, encodeId=b659135011097, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351898, encodeId=2250135189814, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495101, encodeId=6979149510189, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-11 zhaojie88

    #成骨#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1721318, encodeId=0f7d1e2131861, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Sun Sep 22 11:01:00 CST 2019, time=2019-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068826, encodeId=8dad2068826f3, content=<a href='/topic/show?id=9da3203482c' target=_blank style='color:#2F92EE;'>#不同类型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20348, encryptionId=9da3203482c, topicName=不同类型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Mar 25 07:01:00 CST 2019, time=2019-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745303, encodeId=ec911e4530369, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Mon Nov 19 02:01:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068577, encodeId=4ca120685e766, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Sat Mar 09 13:01:00 CST 2019, time=2019-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350110, encodeId=b659135011097, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351898, encodeId=2250135189814, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495101, encodeId=6979149510189, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Sun Nov 11 12:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-11 jj000004

    #骨细胞#

    0