Nature Immunology:维生素A对于保护机体对抗血吸虫感染的重要作用

2017-05-22 MedSci MedSci原创

肝脏的肉芽肿是由炎症反应引起的,因为聚集了密集的巨噬细胞所组成的组织结构。研究人员发现,在感染了曼氏血吸虫后,在虫卵周围形成的肝肉芽肿是机体产生2型免疫反应的结果。对限制组织损伤和肝毒性以及控制寄生虫有重要作用。在缺乏维生素A的情况下,肝脏的肉芽肿的缺失,这表明机体不能有效的将M2型局势细胞转化成M1局势细胞,从而可能导致蠕虫感染期间发生的炎症反应缺陷。

机体组织中的巨噬细胞被认为主要分成两大类,一种是平衡代谢抑制炎症的M2型巨噬细胞,另一种是识别外来致病原的促炎的M1型巨噬细胞。总体来说,在正常情况下,大多数器官组织中,都是以M2型局势细胞占到极大多数。但是当发生感染的情况下,M2型巨噬细胞能够有效的向M1型巨噬细胞转型,从而提供及时的免疫反应。这一转变过程中,有哪些因素促进了这一反应仍然不是很清楚。

在最新一期的Nature Immunology杂志中,Uma Mahesh Gundra及其同事报道了他们的发现:维生素A对于因曼氏血吸虫感染(Schistosoma mansoni)所引起的小鼠腹腔内的M2型巨噬细胞向M1型巨噬细胞的转变是必不可少的。

研究人员首先发现,在感染了曼氏血吸虫后,从老鼠腹腔中分离的巨噬细胞相比于感染前,大部分为M1型巨噬细胞。通过分离比较这些M1型巨噬细胞,发现其与感染前的M2型巨噬细胞在基因组学上有着巨大的差异,表现为更多的促炎基因的上调。

因为维生素A缺乏症是常见的微量营养元素缺乏症,并且常常发生在世界上受慢性蠕虫感染流行的地区,并且视黄酸是维生素A的代谢物,其在调节先天和适应性免疫中具有多重作用。研究人员通过比较给予缺乏维生素A的老鼠与正常饮食的老鼠对于感染血吸虫的不同发现,维生素A缺乏小鼠感染曼氏血吸虫后,在肝部缺少肉芽肿结构(liver granuloma architecture)并且伴随了增加的死亡率。

肝脏的肉芽肿是由炎症反应引起的,因为聚集了密集的巨噬细胞所组成的组织结构。研究人员发现,在感染了曼氏血吸虫后,在虫卵周围形成的肝肉芽肿是机体产生2型免疫反应的结果。对限制组织损伤和肝毒性以及控制寄生虫有重要作用。在缺乏维生素A的情况下,肝脏的肉芽肿的缺失,这表明机体不能有效的将M2型巨噬细胞转化成M1巨噬细胞,从而可能导致蠕虫感染期间发生的炎症反应缺陷。

原始出处:
Uma Mahesh Gundra et al. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nature Immunology 18, 642–653 (2017) doi:10.1038/ni.3734

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    2018-04-03 liye789132251
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GetPortalCommentsPageByObjectIdResponse(id=201221, encodeId=21f82012219b, content=好高端的题目, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIiauEA62nuQI1eE8Ez2rO3yqOkRLH6ha6Lw0x1IBRm0N7g/0, createdBy=e1ff2033933, createdName=187****0626, createdTime=Mon May 22 12:21:19 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-24 ylz8404
  4. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), 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    2017-05-23 Y—xianghai

    学习新知识。

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201221, encodeId=21f82012219b, content=好高端的题目, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIiauEA62nuQI1eE8Ez2rO3yqOkRLH6ha6Lw0x1IBRm0N7g/0, createdBy=e1ff2033933, createdName=187****0626, createdTime=Mon May 22 12:21:19 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-23 吴教授

    今天看了两篇关于维生素A的文章,都对机体有益,在以后的临床诊治过程中,维生素A是不容忽视的。

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), 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  7. 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createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue May 23 19:11:13 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201619, encodeId=25da201619b6, content=今天看了两篇关于维生素A的文章,都对机体有益,在以后的临床诊治过程中,维生素A是不容忽视的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 23 09:33:28 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023478, encodeId=b3bb20234e87c, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201221, encodeId=21f82012219b, content=好高端的题目, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIiauEA62nuQI1eE8Ez2rO3yqOkRLH6ha6Lw0x1IBRm0N7g/0, createdBy=e1ff2033933, createdName=187****0626, createdTime=Mon May 22 12:21:19 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 daiyaozu

    学习了,不错

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), 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    2017-05-22 王秀

    学习了,涨知识了

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Mon May 22 12:35:10 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201222, encodeId=3b72201222bf, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLB2lWFzjaQjxC33RfYGdWpDovtkkdhzWmm9c4lRfGccXhIurkRaLuS5VBHDGBbAOTm2bWazV6x9wg/0, createdBy=342e1692193, createdName=Arthur M, createdTime=Mon May 22 12:22:34 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201221, encodeId=21f82012219b, content=好高端的题目, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIiauEA62nuQI1eE8Ez2rO3yqOkRLH6ha6Lw0x1IBRm0N7g/0, createdBy=e1ff2033933, createdName=187****0626, createdTime=Mon May 22 12:21:19 CST 2017, time=2017-05-22, status=1, ipAttribution=)]
    2017-05-22 Arthur M

    学习了

    0

  10. 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    2017-05-22 187****0626

    好高端的题目

    0

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