Stroke:缺血性卒中患者白细胞计数的全基因组关联研究

2019-10-09 xing.T MedSci原创

由此可见,该研究发现缺血性卒中患者中与白细胞计数相关相关的第一个基因位点,其与急性预后相关。急性表型的遗传分析可能有助于发现与卒中预后相关的遗传因素。该研究的结果表明,与健康状况相比,卒中患者免疫细胞的调节方式有所不同。

免疫细胞在卒中后的第一个24小时(急性期)中起关键作用,与卒中结局相关。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在寻找与卒中急性期白细胞计数相关的遗传危险因素。

研究人员招募了在发病后第一个24小时内白细胞计数数据可用的缺血性卒中患者,研究人员进行了全基因组关联研究和基因表达研究。

该研究的全基因组关联研究招募2064名(发现队列)和407名(重复队列)患者,发现了一个与白细胞计数相关的新基因位点(14q24.3)。经过联合分析(n=2471),还有5个多态性达到了全基因组范围的统计学意义(P<5×10-8)。14q24.3位点与急性卒中预后相关(rs112809786,P=0.036),并与ACOT1和PTGR2基因表达相关。之前在一般人群中与白细胞计数相关的多态性在该研究中没有显示任何意义。

由此可见,该研究发现缺血性卒中患者中与白细胞计数相关相关的第一个基因位点,其与急性预后相关。急性表型的遗传分析可能有助于发现与卒中预后相关的遗传因素。该研究的结果表明,与健康状况相比,卒中患者免疫细胞的调节方式有所不同。 

原始出处:

Nuria P. Torres-Aguila.et al.Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026593

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    2019-10-09 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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