AIM:临床医生需警惕间期结直肠癌的种族/民族差异

2017-05-25 MedSci MedSci原创

间期结直肠癌(Interval colorectal cancer,intervalCRC)也称为结肠镜后结直肠癌(post-colonoscopy colorectal cancer, PCCRC),定义为筛查或监测检查未发现,而在推荐的下一次检查日期之前发生的结直肠癌。在美国,间期CRC占所有CRC患者的3%-8%。但关于间期CRC的种族/民族数据却很少。因此,来自美国的研究人员进行了一项研究

间期结直肠癌(Interval colorectal cancer,intervalCRC)也称为结肠镜后结直肠癌(post-colonoscopy colorectal cancer, PCCRC),定义为筛查或监测检查未发现,而在推荐的下一次检查日期之前发生的结直肠癌。

在美国,间期CRC占所有CRC患者的3%-8%。但关于间期CRC的种族/民族数据却很少。因此,来自美国的研究人员进行了一项研究,以确定患有间期CRC的医疗保险患者的风险不同是否是因为种族/民族的不同,及这种潜在的变化是否会对影响结肠镜检查质量的差异,如息肉检出率(PDR)。

这是一项基于人群的队列研究。参与者是在2002年到2011年间,年龄在66~75岁,接受结肠镜检查的患者,随访到2013年。使用Kaplan Meier曲线和调整后的Cox模型估计累积概率和危险比(HR),间期CRC被定义为结肠镜检查后6至59个月的出现的CRC患者。

研究人员通过235146人-年的随访共确诊了2735例间期CRC。与白人(占46.2%)相比,黑人(52.8%)患者接受结肠镜检查的比例更高且息肉检出率更低。这一比率与间期CRC风险显著相关。随访结束时,患间期CRC的概率在黑人和白人中分别为7.1%和5.8%。与白人相比,黑人患间期CRC的风险显著升高(HR,1.31[95%CI,1.13-1.51]);这种差异在直肠癌(HR,1.70 [CI,1.25-2.31])和远端结肠癌(HR,1.45 [CI,1.00-2.11])中更为明显,在近端结肠癌(HR,1.17[CI,0.96-1.42])中较前两者稍弱。调整PDR后,种族/民族HR未改变,但黑人和白人检出息肉的差异更大。

研究人员认为,在老年医疗患者中,间期结直肠癌的风险在黑人中的风险比白人中更高;差异更为显著的是远端结肠癌和直肠癌症以及息肉检出率。

原始出处:

Fedewa SA, Flanders WD,et al.Racial and Ethnic Disparities in Interval Colorectal Cancer Incidence: A Population-Based Cohort Study.Ann Intern Med. 2017 May 23. doi: 10.7326/M16-1154. [Epub ahead of print]

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    2017-06-15 jyzxjiangqin

    高度警惕间期结直肠癌的差异。

    0

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    2017-05-30 大爰

    学习并分享!!!

    0

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    2017-05-27 临风淑玉

    很好的文章,启示很多!

    0

  4. 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  5. 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content=好好努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri May 26 06:36:27 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 天涯183

    非常好的文章,学习了,很受益

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4DibfxCCVHj71PvJ5RPqpA7fNTlGXqQ9sHFna35iaFic827ukrpJTne6A6oGVsDyhIy1oN0c7OgB7OS6Xeap15Gzl/0, createdBy=46f22066342, createdName=139****2336, createdTime=Fri May 26 07:06:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202667, encodeId=452d20266e29, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 26 07:03:36 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202640, encodeId=99592026401d, content=好好努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri May 26 06:36:27 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 明月清辉

    谢谢分享,学习了

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4DibfxCCVHj71PvJ5RPqpA7fNTlGXqQ9sHFna35iaFic827ukrpJTne6A6oGVsDyhIy1oN0c7OgB7OS6Xeap15Gzl/0, createdBy=46f22066342, createdName=139****2336, createdTime=Fri May 26 07:06:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202667, encodeId=452d20266e29, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 26 07:03:36 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202640, encodeId=99592026401d, content=好好努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri May 26 06:36:27 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 139****2336

    很好

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4DibfxCCVHj71PvJ5RPqpA7fNTlGXqQ9sHFna35iaFic827ukrpJTne6A6oGVsDyhIy1oN0c7OgB7OS6Xeap15Gzl/0, createdBy=46f22066342, createdName=139****2336, createdTime=Fri May 26 07:06:17 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202667, encodeId=452d20266e29, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 26 07:03:36 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202640, encodeId=99592026401d, content=好好努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri May 26 06:36:27 CST 2017, time=2017-05-26, status=1, ipAttribution=)]
    2017-05-26 龙胆草

    学习谢谢分享

    0

  10. 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    2017-05-26 忠诚向上

    好好努力学习

    0

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近日,来自英国伦敦帝国学院的Wendy Atkin博士对中等风险腺瘤患者中,进行结肠癌发病率的异质性,以及结肠镜常规定期监测对结直肠癌发病率的影响进行多中心、回顾性列队研究。该成果在线发表于近期的The Lancet Oncology杂志上。

BJC:合并症可推迟结直肠癌的诊断时间,延误治疗!

先前存在的非癌症临床表现可能使结直肠癌诊断复杂化并延迟。该研究主要目的是评估合并症对结直肠癌的诊断的影响情况。

Theranostics:同济大学黄琦、葛步军课题组发现调控结直肠癌的全新微小RNA

近日,国际生命及医学科学领域的权威学术期刊《Theranostics》杂志上在线发表了同济大学附属同济医院普外科黄琦、葛步军课题组题为“Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4”研究成果,研究发现调控结直肠癌的全新微小RNA。这是世界上首次报道miR-426

Plos One:血清趋化素水平与结直肠癌患者的生活质量独立相关!

结肠直肠癌(CRC)存活者会承受者对其生活质量有显着影响的各种症状(QOL);因此,确定与CRC存活者生活质量相关的临床标志物十分重要。近期,一项发表在杂志Plos One上的研究评估了CRC存活者血清趋化素(chemerin)水平、新确定的促炎脂肪因子以及患者生活质量之间的关系。此项研究共分析了110例CRC存活者的数据。使用酶免疫分析仪测定患者血清趋化素水平。癌症治疗的功能评估(FACT)评分

JCO:Non-V600 BRAF突变应成为转移性结直肠癌新的临床亚型

在评估转移性结直肠癌患者病情时,分子学检测已成为不可缺少的一部分。新一代测序技术(NGS)通常会发现没有明确临床或预后影响的突变,其中codon600以外的BRAF突变(non-V600BRAF突变)就是其中之一。

CCLM:miR-16在结肠直肠腺癌诊断和预后中的应用

结肠直肠腺癌是胃肠道最常见的恶性肿瘤之一,也是西方国家第二大癌症相关死亡原因之一。miR-16广泛参与癌症进展。在本研究中,来自雅典国家和卡波治理大学生物化学与分子生物学系的研究人员对miR-16在结肠直肠腺癌中的潜在诊断和预后效用进行了研究。