Toxicol Sci:研究揭示PM2.5与孤独症谱系障碍之间的联系

2017-11-15 Emma MedSci原创

ASD(Autism Spectrum Disorder)孤独症谱系障碍,是一系列复杂的神经发展障碍性疾病,能影响孩子的社交,行为和交流方面的能力。有孤独症谱系障碍的人,其大脑处理信息的方式异于常人。

ASD(Autism Spectrum Disorder)孤独症谱系障碍,是一系列复杂的神经发展障碍性疾病,能影响孩子的社交,行为和交流方面的能力。有孤独症谱系障碍的人,其大脑处理信息的方式异于常人。孤独症谱系障碍共有三类:自闭症(或典型自闭症),阿斯伯格综合症和待分类的广泛性发展障碍(PDD-NOS)

流行病学研究表明, PM2.5(环境中的细颗粒物)暴露与ASD是密切相关的,然而相关的研究较少。为了评估PM2.5暴露与ASD之间的关系,研究人员选择新生雄性SD大鼠从出生日(PND)8日至22日通过鼻内滴注,暴露于PM2.5(2或20mg/kg体重,每天一次)。

结果发现,新生早期暴露于PM2.5两周后,两组暴露大鼠均表现出典型的孤独症行为特征,包括交流障碍,社会交往不良和新奇性回避。研究人员进一步发现,在选择的5个ASD候选基因中,高剂量PM2.5暴露后,SH3和Shank3(多重锚蛋白重复结构域3)的mRNA水平和蛋白质表达在大鼠海马中显著降低。此外,PM2.5暴露显著增加了海马和前额皮质中的促炎细胞因子IL-1β、IL-6和TNF-α的水平,胶质纤维酸性蛋白(GFAP)和离子化的钙结合衔接分子(IBA1)的表达以及星形胶质细胞和小胶质细胞活化的标志物也分别增加。

该研究提供了关于出生后暴露于环境PM2.5与人类ASD样症状发作之间的联系的新数据,并且说明炎症反应的增加和Shank3在脑中表达的异常可能参与PM2.5暴露引起ASD的过程。

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    2017-11-29 神功盖世

    学习

    0

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    2017-11-27 虈亣靌

    讲解的非常好,值得学习

    0

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    2017-11-22 神功盖世

    雾霾与孤独症

    0

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    2017-11-16 虈亣靌

    学习一下很不错

    0

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    2017-11-15 135****7952平儿

    学了.........

    0

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    2017-11-15 神功盖世

    雾霾与孤独症

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