Intens Care Med:降钙素原可以作为重症患者中暑的标志物吗?

2017-07-27 MedSci MedSci原创

本研究目的为探讨非劳力性中暑患者血清降钙素原(PCT)水平的变化情况。

本研究目的为探讨非劳力性中暑患者血清降钙素原(PCT)水平的变化情况。

本研究为队列研究。研究对象为法国巴黎两所高等专科学校急诊病房和重症监护病房。在2003年8月法国热浪期间,急诊和ICU中53名确诊中暑的患者被纳入研究。

诊断明确的经典中暑患者,用敏感试验方法和重要的常规生物学变量测定这些患者的血清PCT。记录三十天的死亡率。

在纳入的53名患者中,其中有14名(26%)被转入重症监护室(ICU)进行治疗。在30天内,共有24例患者(45%)死亡。PCT平均值为0.58ug/L(95% CI 0.16-1.61),31例(58%)患者PCT大于0.2ug /L(PCT+)。体温大于或等于40摄氏度是唯一与死亡结局显著相关的变量。死亡组和生存组PCT中位值分别为1.4ug/L(0.16-4.71)和0.18ug/L(0.12-1.61)(P=0.22)。所有转入ICU治疗的患者PCT值均升高。PCT+组患者最初表现为明显的全身炎症反应,PCT+组已确诊的微生物或临床感染并没有想象的频繁。

所以我们可以得出结论,对于中暑的患者来说,即使并无任何细菌感染,也可以观察到PCT水平升高。在中暑患者中,PCT不是有效的死亡率预测因子,但可能是一项病情严重程度的预测指标。中暑患者体内可能有一种"非感染"途径的PCT合成模式。

原始出处:

Hausfater P1, Hurtado M, et al. Is procalcitonin a marker of critical illness in heatstroke? Intensive Care Med. 2008 Aug;34(8):1377-83. doi: 10.1007/s00134-008-1083-y. Epub 2008 Mar 28.

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    2022-07-13 小小医者
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  5. 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  6. 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  8. 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    2017-07-28 Thc822

    比较有新意

    0

  9. 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    2017-07-27 楠博One

    学习谢谢分享

    0

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