JAMA:臀部大片红斑病例报道

2016-01-27 MedSci MedSci原创

Caroline Z. Tan, BA1; Roberto Novoa,et al,Erythematous Plaques on the Buttock.jama.2015 http://jama.jamanetwork.com/article.aspx?articleid=2480458

75岁女性患有类风湿关节炎,长期使用强的松治疗。有HSV-2感染,左侧臀部疼痛1周,伴瘙痒皮疹。
 
她否认疼痛部位的任何创伤和皮肤暴露,否认有发热,淋巴结病和其他全身症状。值得注意的是,她最近减少了强的松的用量,从10毫克减到5毫克,之后出现关节炎疼痛症状,在皮疹发生前三天开始使用普瑞巴林。

出疹后,开始使用伐昔洛韦1周,无好转。未接受其他类风湿性关节炎的治疗,如非甾体类抗炎药或抗肿瘤坏死因子α(anti-TNF-α)疗法。物理检查发现左侧臀部(图)局部皮温较高,硬化,红斑边界清晰,伴有小水泡。左腕关节有疼痛、水肿和红斑。其余体格检查无明显异常。



接下来你会做什么?

A.继续使用伐昔洛韦,观察
B.皮肤活组织检查
C.停用强的松
D.局部使用抗真菌药物

答案:

B.皮肤活组织检查

皮肤活检诊断为威尔斯综合征,或嗜酸性蜂窝织炎,通常被误认为是细菌性蜂窝组织炎。诊断时,更多的是使用抗菌治疗,但通常无效。关键的鉴别特性是,缺乏明显的感染入口,如外伤或皮炎、以及引起瘙痒的相关原因,尽管并不是总能找到原因。考虑到这些症状,皮肤活检将有助于确定诊断。继续使用伐昔洛韦而不进行进一步的检查不是正确的做法。考虑到免疫抑制而停用强的松是没有好处的,因为强的松是治疗威尔斯综合征的一线药物。不推荐使用局部的抗真菌治疗。

原始出处:

Caroline Z. Tan, BA1; Roberto Novoa,et al,Erythematous Plaques on the Buttock.jama.2015


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    2016-04-30 吴玲

    学习了知识

    0

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    2017-01-11 Homburg
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    2016-02-14 水滴@

    常见病合并少见病!

    0

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    2016-01-28 胖胖7598

    ?

    0

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    2016-01-28 zhouqu_8

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