Gastric Cancer:上消化道癌患者的脑转移与癌种类和淋巴结转移有关

2020-08-08 MedSci原创 MedSci原创

我们知道上消化道癌(UGC)包括食道和胃食管交界处的腺癌,食道鳞状细胞癌(ESCC)和胃腺癌,这些癌症的发生率在全世界范围内都比较高,并且预后不佳。

        我们知道上消化道癌(UGC)包括食道和胃食管交界处的腺癌,食道鳞状细胞癌(ESCC)和胃腺癌,这些癌症的发生率在全世界范围内都比较高,并且预后不良。2007年,在美国存在上消化道癌的患者诊断出约70000例新的脑转移瘤(BRM)病例,因此,了解BRM发生率和预后意义很重要。

        研究人员从美国安德森癌症中心分析了2002年1月至2016年12月期间接受治疗的2348例上消化道癌患者,消化道癌包括食道和胃食管交界处腺癌(EAC;近端EAC,Siewert I型和II型),食管鳞状细胞癌(ESCC)和胃腺癌(GAC; Siewert III型和胃癌)。研究人员对所有患者进行BRM频率的分析,及危险因素和生存率的统计。

 

        结果显示在2348名患者中,有68名(2.9%)在随访时发生了BRM。BRM发生率如下:近端EAC,4.8%;Siewert I型,5.9%;Siewert II型,2.2%;Siewert III型,0.7%;ESCC:1.2%;胃癌,0%。在多变量分析中,在EAC患者中,Siewert I型和淋巴结转移与BRM的危险因素无关。68名BRM患者的中位总生存期(OS)仅1.16年(95%CI 0.78–1.61)。

        研究最后总结道消化道癌病理表现是腺癌且位于近端或有淋巴结转移的患者发生BRM的风险较高,但是进行BRM治疗后,患者的总体生存期会边长。

 

原始出处:

Kazuto Harada. Et al. Brain metastases in patients with upper gastrointestinal cancer is associated with proximally located adenocarcinoma and lymph node metastases. Gastric Cancer.2020.

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    2021-03-31 许安
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    2020-12-08 skhzy
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    2020-08-10 sodoo
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