Sci Rep:良性前列腺增生生长过程中通过自身抗原识别的补体激活研究

2020-01-16 AlexYang MedSci原创

良性前列腺增生(BPH)的病理生理机制仍旧不清楚。最近,有研究人员利用小鼠模型聚焦了BHP生长过程中的补体激活过程。研究人员从进行了小鼠泌尿生殖窦植入术的小鼠中获取了BPH组织,并通过实时定量RT-PCR、蛋白免疫印迹和免疫组化技术(IHC)分析了小鼠和人类BPH组织中C1q、C3、甘露糖结合凝集素(MBL)、因子B (FB)和C5b-9的局部表达和累积水平,还利用ELISA和IHC分别分析了血清

良性前列腺增生(BPH)的病理生理机制仍旧不清楚。最近,有研究人员利用小鼠模型聚焦了BHP生长过程中的补体激活过程。

研究人员从进行了小鼠泌尿生殖窦植入术的小鼠中获取了BPH组织,并通过实时定量RT-PCR、蛋白免疫印迹和免疫组化技术(IHC)分析了小鼠和人类BPH组织中C1q、C3、甘露糖结合凝集素(MBL)、因子B (FB)和C5b-9的局部表达和累积水平,还利用ELISA和IHC分别分析了血清IgG水平和组织定位。研究发现,与正常组织相比,C1q、C3、MBL、FB和C5b-9高度集中在小鼠BPH组织中。与之不同,与人类正常组织相比,C3、FB和C5b-9,但不包括C1q和MBL,在人类BPH组织中高度富集。研究人员发现了小鼠BPH组织中IgGd的分散定位。另外,热激蛋白90、膜联单白、α-平滑肌肌动蛋白和β-肌动蛋白是BHP模型中IgG自身抗体识别靶标。

最后,研究人员指出,他们的结果表明了BHP生长过程中补体的激活很可能通过自身抗体经典的激活途径来激发。

原始出处:

Junya Hata, Takeshi Machida, Kanako Matsuoka et al. Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia. Sci Rep. 30 Dec 2019

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