Front Syst Neurosci:降低术中额叶α波功率或可预防高危患者术后谵妄与POCD的发生

2017-05-31 MedSci MedSci原创

每年有超过1600万的美国老人接受全麻手术,而高达40%的患者术后出现谵妄和/或认知功能障碍(POCD)。谵妄和POCD的发生与生活质量下降,提前退休, 1年死亡率增加,和长期的认知能力下降都相关。 因此,许多研究者认为麻醉和手术产生的严重应激对大脑老化产生了明显地影响,患者承受应激的能力不足则会增加谵妄和POCD的发生危险。术前认知功能较低的患者谵妄与POCD的发生风险会增加,但是患者术前

每年有超过1600万的美国老人接受全麻手术,而高达40%的患者术后出现谵妄和/或认知功能障碍(POCD)。谵妄和POCD的发生与生活质量下降,提前退休, 1年死亡率增加,和长期的认知能力下降都相关。

因此,许多研究者认为麻醉和手术产生的严重应激对大脑老化产生了明显地影响,患者承受应激的能力不足则会增加谵妄和POCD的发生危险。术前认知功能较低的患者谵妄与POCD的发生风险会增加,但是患者术前的认知功能并不能常规评估,且目前并未发现术中可预测较低的术前认知功能的生理因子。

由于全麻可引起枕叶脑电图(EEG)α波(8–12 Hz)的功率降低,并增加额叶的功率,且老年人中麻醉诱导前α波功率减少,因此,研究人员假设,较低的术中额叶α波功率或与较低的术前认知功能相关。

该研究中结果表明,较低的术中额叶α波功率与较低的术前认知功能相关,这表明较低的术前额叶α功率可作为一个生理指标用于确定术前认知功能较低的老年患者。降低术中额叶α波功率可以作为高危患者预防术后谵妄与POCD发生的一个治疗干预措施。更普遍的是,这些结果表明,理解大脑对麻醉药物反应的个体差异可以作为神经认知功能的探针,且还可作为衡量老年人神经认知功能的一个有用的措施。

原始出处:

Charles M. Giattino, Jacob E. Gardner, et al., Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults. Front Syst Neurosci. 2017; 11: 24. Published online 2017 May 8. doi:  10.3389/fnsys.2017.00024.

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    2017-06-02 lsndxfj
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    2017-06-01 飛歌

    学习了很有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1955751, encodeId=bbf51955e51a7, content=<a href='/topic/show?id=5b0b1022667b' target=_blank style='color:#2F92EE;'>#高危患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102266, encryptionId=5b0b1022667b, topicName=高危患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sat Aug 05 21:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307294, encodeId=c3a0130e2943c, content=<a href='/topic/show?id=2fbb61104e6' target=_blank style='color:#2F92EE;'>#术后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61104, encryptionId=2fbb61104e6, topicName=术后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5462342, createdName=sunmin0219, createdTime=Fri Jun 02 12:42:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364184, encodeId=a0a213641845a, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Jun 02 12:42:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205088, encodeId=f8f0205088c6, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Jun 01 06:42:37 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204979, encodeId=2cb62049e9c3, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Jun 01 00:06:27 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204955, encodeId=816e204955a6, content=不错的文章,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed May 31 22:55:36 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204941, encodeId=1c03204941de, content=学习点,不过只是涨个知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Wed May 31 22:34:16 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-01 txqjm

    谢谢了,学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1955751, encodeId=bbf51955e51a7, content=<a href='/topic/show?id=5b0b1022667b' target=_blank style='color:#2F92EE;'>#高危患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102266, encryptionId=5b0b1022667b, topicName=高危患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sat Aug 05 21:42:00 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307294, encodeId=c3a0130e2943c, content=<a href='/topic/show?id=2fbb61104e6' target=_blank style='color:#2F92EE;'>#术后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61104, encryptionId=2fbb61104e6, topicName=术后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5462342, createdName=sunmin0219, createdTime=Fri Jun 02 12:42:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364184, encodeId=a0a213641845a, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Fri Jun 02 12:42:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205088, encodeId=f8f0205088c6, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Jun 01 06:42:37 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204979, encodeId=2cb62049e9c3, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Thu Jun 01 00:06:27 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204955, encodeId=816e204955a6, content=不错的文章,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed May 31 22:55:36 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204941, encodeId=1c03204941de, content=学习点,不过只是涨个知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuBA90ng5ibXMmibn1feGOQ2cjw0S48DKsF0icicFlmRxwHibIic2TNGd22vVqkKRMj2cRSWbpqZAPBPgdt/0, createdBy=81031668757, createdName=林3301, createdTime=Wed May 31 22:34:16 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-05-31 1e1b8538m79(暂无匿称)

    不错的文章,值得学习

    0

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    2017-05-31 林3301

    学习点,不过只是涨个知识

    0

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