JCEM:嗜铬细胞瘤导致骨量减少和骨吸收增加:交感活性对人体骨骼的重要性!

2017-06-10 xing.T MedSci原创

由此可见,该研究首次提供了临床证据显示在嗜铬细胞瘤中交感神经过度兴奋可通过骨损失(尤其是骨小梁)以及骨重吸收的增加导致对人体骨骼的不良影响。

尽管交感神经活性对啮齿类动物的骨代谢有明显的生物学意义,但它在人类中的作用仍然存在疑问。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在阐明人类交感神经系统与骨骼之间的相关性。

在620例连续就诊的新诊断肾上腺偶发瘤患者中,31例经病理证实的嗜铬细胞瘤(儿茶酚胺分泌的神经内分泌肿瘤)患者和280例无功能肾上腺偶发瘤患者分别被定义为病例组和对照组。

在调整混杂因素后,有7.2%的嗜铬细胞瘤患者腰椎出现了较低的骨量,33.5%的患者血清I型胶原羧基末端肽(CTX)较高,相比于那些没有嗜铬细胞瘤的患者(分别有P=0.016和0.001),而在股骨颈和全髋关节部位的骨密度(BMD)以及血清骨碱性磷酸酶(BSALP)水平在两组间无统计学差异。嗜铬细胞瘤患者下腰椎BMD较低其比值比(OR)为3.31(95%可信区间为1.23-8.56)。然而,对于股骨颈和全髋关节骨密度较低的ORs根据嗜铬细胞瘤的有无并没有差别。嗜铬细胞瘤肾上腺切除术后血清CTX水平降低了35.2%,而血清BSALP水平没有明显变化。

由此可见,该研究首次提供了临床证据显示在嗜铬细胞瘤中交感神经过度兴奋可通过骨损失(尤其是骨小梁)以及骨重吸收的增加导致对人体骨骼的不良影响。

原始出处:

Beom-Jun Kim,et al. Lower bone mass and higher bone resorption in pheochromocytoma: Importance of sympathetic activity on human bone. J Clin Endocrinol Metab. 2017. https://doi.org/10.1210/jc.2017-00169

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    2018-05-12 smallant2015
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    2017-12-25 clmlylxy
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    2017-10-05 mgqwxj
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  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209373, encodeId=40f72093e392, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 11 11:06:42 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-09-06 achengzhao
  6. 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  7. 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href='/topic/show?id=75991016300c' target=_blank style='color:#2F92EE;'>#骨吸收#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Mon Jun 12 05:00:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209599, encodeId=5150209599cb, content=将来的医生可以让这些人的成果在病人身上有所体现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCxzIqGgHGpnv0v7a7MZQHVVjxvBfHWenpTPmFhDxa6vn3qno88vft2DRqYcyUBQFCRouANp2WgxQ/0, createdBy=b35a44222, createdName=kane35, createdTime=Mon Jun 12 02:59:25 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209373, encodeId=40f72093e392, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 11 11:06:42 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209373, encodeId=40f72093e392, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 11 11:06:42 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 徐岩
  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209373, encodeId=40f72093e392, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 11 11:06:42 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 kane35

    将来的医生可以让这些人的成果在病人身上有所体现。

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209373, encodeId=40f72093e392, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 11 11:06:42 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-11 tanxingdoctor

    学习啦谢谢分享

    0

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