科学家发现衰老细胞和癌细胞中存在相同的蛋白质

2017-03-08 佚名 来宝网

【衰老和早期癌症新靶向】根据伦敦玛丽皇后大学的研究发现,蛋白质在老化细胞中担当着未知的角色,研究人员希望这一发现可以对衰老和早期癌症的治疗起到作用。

【衰老和早期癌症新靶向】根据伦敦玛丽皇后大学的研究发现,蛋白质在老化细胞中担当着未知的角色,研究人员希望这一发现可以对衰老和早期癌症的治疗起到作用。


我们身体中的器官和组织是由大量细胞构成的,这些细胞相互作用调节身体功能,维持健康,然而,在衰老的细胞和早期癌症患者的细胞中却发现了一些相同的 “异常” 细胞。

研究捕获了不断增多的 “衰老” 细胞,它们影响着组织的功能,当衰老细胞增殖失败时,它们会试图与邻近的细胞沟通,而沟通的途径主要是释放炎症蛋白质。发表于《细胞报告》的研究中, 描述了衰老细胞交流的方法是通过整合素膜蛋白,其中包括一种在衰老细胞中高度表达的 “整合素β3” 蛋白质。

研究人员表示,“这是整合素β3 首次证明在老化过程中的角色,这一研究为今后治疗早期癌症和老化的治疗贡献一份力量。”

原始出处:Valentina Rapisarda, Michela Borghesan, Veronica Miguela, et al.Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway.Cell Reports.7 March. 2017.

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    2017-03-15 喜婷

    学习了

    0

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    2017-03-10 yxch36
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