Liver Int:肝脏弹性成像恶性肿瘤预测(LEMP)评分对局灶性肝损害的预测

2018-06-07 MedSci MedSci原创

综合方法展示出,通过使用RT-2D-SWE正确区分96%的患者的良、恶性FLL。

研究背景和目的:本研究的目的是分析局灶性肝损害的弹性体特征及实时二维弹性成像的诊断性能,以鉴别局灶性肝损害良恶性。

研究方法:经腹部超声诊断为FLL的连续患者,经肋间,在肝右叶实施RT-2D-SWE。FLL的性质是通过诊断检查确定的,包括至少一种对比增强的成像方式(MDCT/MRI),怀疑有转移性疾病时对目标器官进行检查,不确定的情况下进行FLL活检。

研究结果:研究分析了196例(60岁中位[50-68],50.5%男性)患者,存在259处FLLs (57例肝细胞癌,17例胆管癌,94例转移瘤,71例血管瘤,20例局灶性结节增生),其中70例患者为(27%)肝硬化患者。恶性病灶较硬(P < 0.001),内部硬度变异性较高(P = .001)。对于恶性肿瘤,损伤硬度的最佳截止值为22.3 kPa(敏感性83%;特异性86%;阳性预测值[PPV] 91.5%;阴性预测值[NPV] 73%)。病变硬度< 14kpa时,NPV为96%,病变硬度>32.5 kPa时,PPV为96%。在逐步logistic回归(P < .05)中,病变硬度、损伤/病变硬度比和损伤硬度变化显著预测了恶性肿瘤的发生(P < .05);并被用于构建新的肝脏弹性成像恶性肿瘤预测(LEMP)评分,准确率为96.1%。

研究结论:综合方法展示出,通过使用RT-2D-SWE正确区分96%的患者的良、恶性FLL。

原始出处:

Grgurevic I, Bokun T, Salkic NN, et al. Liver elastography malignancy prediction score for noninvasive characterization of focal liver lesions.Liver Int, 2018, 38(6), 1055-1063.

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    2018-06-12 三生有幸9135

    学习一下谢谢

    0

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    2018-06-11 三生有幸9135

    学习一下谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1645972, encodeId=2a9116459e208, content=<a href='/topic/show?id=663550088ef' target=_blank style='color:#2F92EE;'>#弹性成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50088, encryptionId=663550088ef, topicName=弹性成像)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0eb23278887, createdName=tamgche, createdTime=Sun Sep 23 04:51:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009681, encodeId=d058200968162, content=<a href='/topic/show?id=c7804e581bc' target=_blank style='color:#2F92EE;'>#局灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47581, encryptionId=c7804e581bc, topicName=局灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Sat May 11 11:51:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635742, encodeId=4de81635e421a, content=<a href='/topic/show?id=b7128123013' target=_blank style='color:#2F92EE;'>#肝损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81230, encryptionId=b7128123013, topicName=肝损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a32e22523419, createdName=ms9476844295372110, createdTime=Sat Dec 15 06:51:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323468, encodeId=85ef323468b4, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Jun 12 06:45:07 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323349, encodeId=e47632334936, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:58:21 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322913, encodeId=b6f7322913d0, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:57:34 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322380, encodeId=32be32238050, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Jun 08 06:14:06 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322334, encodeId=527f32233438, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Thu Jun 07 23:07:25 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-06-10 三生有幸9135

    学习一下谢谢

    0

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    2018-06-08 三生有幸9135

    学习一下谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1645972, encodeId=2a9116459e208, content=<a href='/topic/show?id=663550088ef' target=_blank style='color:#2F92EE;'>#弹性成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50088, encryptionId=663550088ef, topicName=弹性成像)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0eb23278887, createdName=tamgche, createdTime=Sun Sep 23 04:51:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2009681, encodeId=d058200968162, content=<a href='/topic/show?id=c7804e581bc' target=_blank style='color:#2F92EE;'>#局灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47581, encryptionId=c7804e581bc, topicName=局灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Sat May 11 11:51:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635742, encodeId=4de81635e421a, content=<a href='/topic/show?id=b7128123013' target=_blank style='color:#2F92EE;'>#肝损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81230, encryptionId=b7128123013, topicName=肝损害)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a32e22523419, createdName=ms9476844295372110, createdTime=Sat Dec 15 06:51:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323468, encodeId=85ef323468b4, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Jun 12 06:45:07 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323349, encodeId=e47632334936, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:58:21 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322913, encodeId=b6f7322913d0, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Jun 10 05:57:34 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322380, encodeId=32be32238050, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Jun 08 06:14:06 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322334, encodeId=527f32233438, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Thu Jun 07 23:07:25 CST 2018, time=2018-06-07, status=1, ipAttribution=)]
    2018-06-07 131****2916

    不错的文章值得推荐

    0

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