J Gene Med:骨形态发生蛋白-2在肌肉组中作为成骨诱导剂的效果

2018-06-30 MedSci MedSci原创

https://www.ncbi.nlm.nih.gov/pubmed/29953687

既往研究表明,骨形态发生蛋白-2(BMP-2)基因活化的肌肉组织片段可在临床前动物模型中可促进大块骨缺损的修复。本研究探究了BMP-2对肌肉组织碎片的骨诱导作用是否可以通过使用异二聚体BMP-2/6或BMP-2/7来增强。

将大鼠的骨骼肌组织片段在正常培养基、成骨培养基或补充有低浓度(50ng/ml)或高浓度(200ng /ml)的重组人BMP-2、BMP-2/6或BMP-2/7的成骨培养基中培养20天。通过定量逆转录酶聚合酶链式反应、茜素红S染色、免疫组织化学和组织形态学评估骨诱导。

结果显示,与两种异二聚体相比,BMP-2在肌肉组织内的成骨分化诱导能力更强。即使是低浓度的BMP-2也会较高浓度的异二聚体有更多的钙沉积、骨特异性基因表达和蛋白质产生。在高浓度下,BMP-2/7比BMP-2/6具有更强的成骨作用。

综上所述,该研究结果表明,同源二聚体BMP-2在较低浓度下诱导肌肉中的成骨细胞生成,并且比异二聚体BMP-2/6或BMP-2/7具有更强的作用。

原始出处:

Betz VM, Ren B, et al., Bone Morphogenetic Protein-2 is a stronger inducer of osteogenesis within muscle tissue than heterodimeric Bone Morphogenetic Protein-2/6 and -2/7: implications for expedited gene-enhanced bone repair. J Gene Med. 2018 Jun 28:e3042. doi: 10.1002/jgm.3042.

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    2019-02-07 cy0324
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    2018-07-02 zhaojie88
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2049053, encodeId=900720490538b, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Feb 07 21:36:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055345, encodeId=160f205534518, content=<a href='/topic/show?id=d0b7101851ee' target=_blank style='color:#2F92EE;'>#骨诱导#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101851, encryptionId=d0b7101851ee, topicName=骨诱导)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=278f2500221, createdName=12498fa0m11暂无昵称, createdTime=Thu Feb 07 07:36:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821608, encodeId=79a2182160880, content=<a href='/topic/show?id=ebbe1016584f' target=_blank style='color:#2F92EE;'>#骨形态发生蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101658, encryptionId=ebbe1016584f, topicName=骨形态发生蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Sat May 11 19:36:00 CST 2019, time=2019-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351759, encodeId=14241351e5921, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 02 14:36:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608910, encodeId=7a9d16089104b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 02 14:36:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328317, encodeId=a50432831e86, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 01 00:57:38 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0