Ann Rheum Dis：类风湿性关节炎的流行病学正在改变吗？1985-2014年人群发病率研究结果

2020-02-19 xiangting MedSci原创

使用1987 ACR标准，与前20年相比，2005-2014年RF阴性RA的发病率明显升高，而RF阳性RA的发病率下降。

这项研究旨在探讨与1995-2004年和1985-1994年比较，2005年至2014年类风湿性关节炎（RA）的总体和不同血清学状态的发病率趋势。

研究人员在一个基于人群的初始队列中评估RA的发病率趋势，该队列纳入1985年1月1日至2014年12月31日首次满足1987美国风湿病学会（ACR）RA标准的18岁以上个体。估算发病率并根据2010年的美国白人进行年龄和性别调整。使用Poisson回归方法分析了发病率趋势。

2005-2014年的发病率队列包括427名患者：平均年龄55.4岁，女性68％，类风湿因子（RF）阳性占51％，抗环瓜氨酸肽抗体阳性50％。2005-2014年，按年龄和性别调整后的RA总体年发病率为41/100000（年龄调整发病率：女性为53/100000，男性为29/100000）。尽管这些估算值与1995-2004年相似，但与前20年相比，2005-2014年RF阳性RA的发病率有所下降（p=0.004），RF阴性病例则相应增加（p＜0.001）。从早期到最近几年，吸烟率下降而肥胖率升高。

使用1987 ACR标准，与前20年相比，2005-2014年RF阴性RA的发病率明显升高，而RF阳性RA的发病率下降。2005-2014年RA的总体发病率与前10年相似。环境因素的患病率改变，例如吸烟、肥胖等，可能导致了这些趋势。这些趋势是否能代表RA血清学特征的变化仍需要进一步调查。

原始出处：

Elena Myasoedova. Is the epidemiology of rheumatoid arthritis changing? Results from a population-based incidence study, 1985–2014. Ann Rheum Dis. 17 February 2020.

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2020-10-25 1249894fm84暂无昵称

#研究结果#

35 0
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2020-10-14 lifestar

#发病率#

38 0
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2021-01-18 cmj8wellington

#Dis#

0 0
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2020-07-05 ms3830150583600765

#985#

40 0
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2020-02-21 lmm397

#关节炎#

34 0
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2020-02-21 ms4964546379600229

#类风湿#

28 0
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2020-02-21 xugumin

#流行病#

29 0
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2020-02-21 ms1467340776200723

#风湿性关节炎#

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