Neurology:多种慢性疾病对多发性硬化确诊以及死亡风险的影响

2017-09-22 MedSci MedSci原创

研究表明,慢性疾病对多发性硬化的确诊以及患者生存具有显著影响

近日,研究人员考察了慢性疾病对多发性硬化(MS)诊断时间和死亡率的影响。

研究人员开展了一项基于人群的全国性队列研究,1980-2005年间确诊的丹麦多发性硬化患者参与。采用非条件多元逻辑回归模型以及时变协变量Cox回归考察慢性病对多发性硬化诊断以及死亡的影响。

1980-2005年间共确诊了8947名多发性硬化患者。研究发现,脑血管疾病(2.01 [1.44-2.80]; <0.0005)、心血管疾病(4.04 [2.78-5.87]; <0.0005)、肺病(1.93 [1.42-2.62]; <0.0005)、糖尿病(1.78 [1.04-3.06]; 0.035)以及肿瘤(2.10 [1.20-3.67]; 0.009)可显著延缓多发性硬化的确诊时间,而精神疾病(2.42 [1.67-3.01]; <0.0005)、脑血管病(2.47 [2.05-2.79]; <0.0005)、心血管病 (1.68 [1.39-2.03]; <0.0005)、肺病(1.23 [1.01-1.50]; 0.036)、糖尿病(1.39 [1.05-1.85]; 0.021)、肿瘤(3.51 [2.94-4.19]; <0.0005)以及帕金森病(2.85 [1.34-6.06]; 0.007)显著提高多发性硬化患者的死亡率。

研究表明,慢性疾病对多发性硬化的确诊以及患者生存具有显著影响。

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    2018-06-24 jml2009
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    2017-09-27 yinhl1978
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    2017-09-23 meiliwuxian

    学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1889795, encodeId=d5b31889e95ba, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Jun 24 04:25:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000113, encodeId=e0f920001133c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 27 11:25:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255680, encodeId=38c7125568073, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Sep 24 06:25:00 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246873, encodeId=7c6b2468e343, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Sat Sep 23 08:25:19 CST 2017, time=2017-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246799, encodeId=432c246e9950, content=谢谢分享.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat Sep 23 06:39:41 CST 2017, time=2017-09-23, status=1, ipAttribution=)]
    2017-09-23 明天会更好!

    谢谢分享.学习了!

    0

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