JAMA Neurol:癫痫妇女的妊娠结局

2017-07-10 zhangfan MedSci原创

研究表明,孕期癫痫导致不良妊娠结局的风险增加,孕期服用抗癫痫药物是相对安全的

目前,探讨孕期癫痫以及抗癫痫药物(AED)治疗与妊娠结局之间的关系尚未明确。近日研究人员考察了孕期癫痫与妊娠结局的关系以及抗癫痫药物的影响。研究人员考察了1997-2011年间,孕22周以上单胎新生儿、产妇以及药物服用资料。主要终点是妊娠、分娩及围产儿结局。在调整产妇年龄,国籍,教育水平,伴侣,身高,孕早期体重指数,吸烟,生产年份,孕期糖尿病,高血压以及精神疾病后,采用多变量对数线性回归分析调整后风险(aRRs)以及95%置信区间。研究包含1429652名新生儿,其中有3586名癫痫产妇以及对应5373名新生儿。癫痫队列产妇首次分娩年龄30.54岁,相对于非癫痫产妇,癫痫产妇不良妊娠及分娩结局风险增加,其中前期子痫(aRR 1.24;95% CI,1.07-1.43),感染(aRR,1.85;95% CI,1.43-2.29),胎盘早剥(aRR,1.68;95% CI,1.18-2.38)、引产(aRR,1.31;95% CI,1.21-1.40),择期剖宫产(ARR,1.58;95% CI,1.45-1.71)和急救剖宫产术(ARR,1.09;95% CI,1.00-1.20)。癫痫

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    2017-09-20 yinhl1978
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    2017-07-10 虈亣靌

    讲解的非常好,值得学习

    0

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    2017-07-10 半夏微凉

    阅读了谢谢分享

    0

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    2017-07-10 蔬菜

    谢谢分享,学习了

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    2017-07-10 152****8376

    谢谢分享受益匪浅

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