JAHA:终末期肝病患者多巴酚丁胺负荷灌注超声心动图的预测价值何如?

2017-02-21 xing.T MedSci原创

由此可见,负荷MVP评估是当前肝脏移植候选者心血管结局的重要预测手段。

在肝脏移植的心脏风险评估中需要更敏感的检测手段来发现隐匿性冠状动脉疾病以及微血管和功能性心脏异常。因为多巴酚丁胺负荷灌注超声心动图可以为局部收缩和舒张功能以及微血管灌注(MVP)提供评估,近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员试图评估在肝脏移植中多巴酚丁胺负荷灌注超声心动图的增量价值。

研究人员在296例2008年至2014年期间接受肝脏移植的成人终末期肝病和收缩功能正常的患者中评估了多巴酚丁胺负荷超声心动图的预测价值。该研究的主要终点为在肝移植术后心血管死亡、非致死性心肌梗死和/或持续性室性心律失常

在这些参与者中,肝功能衰竭的主要原因为C型肝炎(25%)和非酒精性脂肪性肝病(13%)。在18例(6%)患者中观察到在负荷时异常的MVP,而出现舒张功能障碍的有109例患者(94例患者为1级,15例患者为2级)。一半的患者(14例中的7例)有异常MVP进行血管造影发现了显著心外膜疾病,这些患者在接受肝脏移植之前,进行血运重建。尽管采取了这些干预措施,在9例(3%)参与者中还是发生了研究的主要终点。多巴酚丁胺负荷灌注超声心动图期间有异常MVP的患者在后续肝脏移植中发生心血管疾病的风险增加7倍。评估了临床变量、左心室射血分数、舒张功能和负荷诱导的室壁运动异常或MVP缺陷的Cox比例风险模型结果表明异常的MVP是主要终点的唯一独立预测因子(P=0.004;风险比为7.7)。

由此可见,负荷MVP评估是当前肝脏移植候选者心血管结局的重要预测手段。

原始出处:

Bipul Baibhav,  et al. Predictive Value of Dobutamine Stress Perfusion Echocardiography in Contemporary End‐Stage Liver Disease.JAHA.2017. http://jaha.ahajournals.org/content/6/2/e005102.

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    2017-02-24 1771ae4158m

    学习一下很不错

    0

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    2017-02-24 1771ae4158m

    学习一下很不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2017918, encodeId=2f0a201e918e4, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Fri May 19 08:52:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1651004, encodeId=d62d16510042e, content=<a href='/topic/show?id=2aa35090181' target=_blank style='color:#2F92EE;'>#心动图#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50901, encryptionId=2aa35090181, topicName=心动图)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7624121693, createdName=zhu_jun9845, createdTime=Wed Oct 18 08:52:00 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1693447, encodeId=baf3169344ec1, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Fri Apr 14 22:52:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177660, encodeId=255a1e7660c6, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Feb 24 00:19:31 CST 2017, time=2017-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177659, encodeId=34f21e7659ed, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Feb 24 00:19:01 CST 2017, time=2017-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267397, encodeId=83ec126e39737, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Feb 23 03:52:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626462, encodeId=abf0162646239, content=<a href='/topic/show?id=558b100221c7' target=_blank style='color:#2F92EE;'>#预测价值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100221, encryptionId=558b100221c7, topicName=预测价值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5f621038683, createdName=changjitao2016, createdTime=Thu Feb 23 03:52:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177284, encodeId=063d1e7284ca, content=学习签到,赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Tue Feb 21 14:49:10 CST 2017, time=2017-02-21, status=1, ipAttribution=)]
    2017-02-23 zhaohui6731
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    2017-02-21 shaosai

    学习签到,赚积分

    0