Chest:患COPD肺移植候选人的生存率

2017-10-20 xiangting MedSci原创

基于BODE评分的预后评估高估了COPD肺移植候选人的死亡风险。

体质量指数、梗阻、呼吸困难和运动能力(BODE)评分可用于评估慢性阻塞性肺疾病(COPD)肺移植的预后,但尚未得到验证。COPD中大部分死亡可归因于是移植禁忌的合并症。研究人员假设被选为移植候选人的COPD患者生存率更高,优于传统的BODE评分解释。

根据肺移植候选人器官共享数据库中COPD患者(n = 4,377)的BODE评分,对生存率进行了回顾性分析。并与COPD患者队列进行比较,其中对BODE评分进行了验证。 

UNOS队列中BODE评分第四分位的中位生存率为59个月(95%CI 51-77个月),BODE验证队列为37个月(95%CI 29-42个月)。在控制BODE评分并纳入肺移植作为竞争终点的模型中,BODE验证队列的死亡风险较高(SHR 4.8,95%CI 4.0-5.7,p <0.001)。BODE评分的第四分位数的风险差异最大(SHR 6.1, 95%CI 4.9-7.6,p <0.001)。

基于BODE评分的预后评估高估了COPD肺移植候选人的死亡风险。这可能是由于肺移植评估筛选过程中合并症的发生率较低。

原始出处:
Robert M. Reed, et al. Survival of Lung Transplant Candidates with COPD: BODE Reconsidered. Chest. 17 October 2017. 

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    2018-04-13 871538379

    希望该技术越来越成熟

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    2018-07-29 Smile2680
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    2017-10-22 guoyibin
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    2017-10-20 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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    2017-10-20 131****1460

    学习了受益匪浅

    0

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    2017-10-20 戒馋,懒,贪

    谢谢分享

    0

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    2017-10-20 清风拂面

    谢谢分享.学习了

    0

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