Diabetologia:终止妊娠和绝育的女性与幼年1型糖尿病发病

2017-12-31 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于终止妊娠和绝育的女性与幼年1型糖尿病发病的研究。这项研究的目的是探讨1型糖尿病与女性生殖健康指标之间的关系,重点是终止妊娠和绝育。 研究人员进行了一项注册研究队列研究,涉及2281名儿童期发病的1型糖尿病女性,年龄和出生地与无糖尿病的女性相匹配,每位糖尿病女性与两名对照参与者匹配。研究人员比较了25年间1型糖尿病女性和没有的女性终

近日,国际杂志 《Diabetologia》上在线发表一项关于终止妊娠和绝育的女性与幼年1糖尿病发病的研究。这项研究的目的是探讨1糖尿病与女性生殖健康指标之间的关系,重点是终止妊娠和绝育。

研究人员进行了一项注册研究队列研究,涉及2281儿童期发病的1糖尿病女性,年龄和出生地与无糖尿病的女性相匹配,每位糖尿病女性与两名对照参与者匹配。研究人员比较了25年间1型糖尿病女性和没有的女性终止妊娠和绝育的频率,以及估计的标准化发病率(SIR)。在统计学上测试平滑年龄和期限对怀孕或绝育终止发生率的影响。

研究发现,糖尿病女性的妊娠终止(SIR 1.67; 95CI 1.51,1.86)和绝育(SIR 1.69; 95CI 1.56,1.83)比对照组女性高。近年来,糖尿病女性的绝育量已经下降,与对照组女性的差异已经消失。这两种手术的适应症显示出统计学上非常显著的差异:在对照组女性中,孕妇的手术适应证几乎不存在(<1%),但糖尿病女性终止妊娠为23.6%和绝育为22.9%。

研究结果表明,与其他女性相比,糖尿病女性终止妊娠和绝育的适应症不同。1型糖尿病妇女的妊娠终止仍然比没有糖尿病的女性更为常见,但近年来绝育率的差异已经消失。

原始出处:

Lena Sjöberg, Risto Kaaja, Mika Gissleret al. Termination of pregnancy and sterilisation in women with childhood-onset type 1 diabetes

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视网膜微血管变化可能反映胰岛素抵抗。研究人员检查了基线和产后5年母亲队列中妊娠期间视网膜微血管变化与随后的糖代谢异常的风险之间的关系。