DIABETOLOGIA:母亲1型糖尿病与儿童肥胖和后代代谢健康的关系如何?

2018-12-23 MedSci MedSci原创

之前研究表明,暴露于宫内高血糖环境会增加后代后期超重或代谢异常的风险,但目前,仍然缺乏由母体1型糖尿病影响怀孕的确凿证据。本研究旨在分析母体1型糖尿病与后代代谢健康之间的关系,并研究出生体重和/或后代代谢组的变化是否属于潜在途径的变化。 研究人员分析了分别来自TEENDIAB和BABYDIAB / BABYDIET队列的610和2169个后代的数据,这些后代均具有1型糖尿病的一级亲属。采用混

之前研究表明,暴露于宫内高血糖环境会增加后代后期超重或代谢异常的风险,但目前,仍然缺乏由母体1糖尿病影响怀孕的确凿证据。本研究旨在分析母体1糖尿病与后代代谢健康之间的关系,并研究出生体重和/或后代代谢组的变化是否属于潜在途径的变化。

研究人员分析了分别来自TEENDIABBABYDIAB / BABYDIET队列的6102169个后代的数据,这些后代均具有1糖尿病的一级亲属。采用混合回归模型,在0.3-18岁的纵向研究,将1型糖尿病母亲的子女与非糖尿病母亲但父亲或兄弟姐妹患有1型糖尿病的子女进行比较。对来自TEENDIAB500个个体中进行非靶向代谢组学测量,并分析母体1型糖尿病和后代超重情况。

结果显示,1型糖尿病母亲的后代比非糖尿病母亲的后代具有更高的BMI SD评分SDS)和超重风险(例如,TEENDIAB 2.40中超重状态的OR [95CI 1.41,4.06]) 。此外,即使调整潜在的混杂因素和出生体重,1型糖尿病母亲的后代的腰围SDS,葡萄糖,胰岛素和C肽的空腹水平,胰岛素抵抗和腹部肥胖也明显增加。发现与雄激素类固醇和支链氨基酸相关的代谢物模式与后代的超重状态有关,但在母体1型糖尿病和后代中的代谢物浓度之间未观察到显着相关性。

研究结果表明,母亲1型糖尿病与后代的超重状态和后代代谢健康有关,但这不太可能是由后代代谢组的改变所引起的。

原始出处:

Anitha Pitchika, Manja Jolink, Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study

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    2019-01-03 Dr-z

    学习了

    0

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    2019-01-03 Dr-z

    很好,学习了

    0

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    2018-12-23 misszhang

    谢谢MedSci提供最新的资讯

    0

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