Hepatology：HBV pgRNA可用于乙肝相关肝癌的肿瘤分型和预后预测

2018-01-04 李昕宇迟秀梅牛俊奇临床肝胆病杂志

【据《Journal of Hepatology》2017年12月报道】题：HBV pgRNA可用于乙肝相关肝癌的肿瘤分型和预后预测（作者Boris Halgand 等）

【据《Journal of Hepatology》2017年12月报道】题：HBV pgRNA可用于乙肝相关肝癌的肿瘤分型和预后预测（作者Boris Halgand 等）

HBV是引起肝细胞癌（HCC）的主要病因，但在HCC组织中HBV的复制尚不清楚。本研究分析肿瘤和非肿瘤肝脏样本中的病毒和细胞参数。

纳入99例乙肝表面抗原（HBsAg）阳性、病毒学得到抑制、接受肿瘤切除或肝移植的HCC患者，对HBV DNA总量、RNA、共价闭合环状DNA（cccDNA）以及pgRNA等HBV活动性复制的标志物进行检测。

在大多数肿瘤病例和非肿瘤肝组织中，均可检出HBV DNA总量和RNA，但只有部分肿瘤样本中可检出HBV cccDNA和pgRNA（检出率分别为39%和67%，P<0.01）。相比之下，在大多数非肿瘤肝组织中可检出HBV cccDNA和pgRNA（检出率分别66%和90%；P < 0.01）。对11例源于游离基因形式的X基因进行测序表明，肿瘤样本和配对的非肿瘤肝组织中的HBV基因型不同，为肿瘤组织中的HBV复制提供了进一步证据。

肿瘤组织中可检出pgRNA和cccDNA与未发生肿瘤微血管侵犯和患者生存率较高有关。通过安捷伦微阵列对基因表达进行分析表明，pgRNA阳性HCC，其细胞周期和DNA修复标志物的水平较低，并且表达HBV受体-钠离子-牛磺胆酸共转运多肽（NTCP），表明肿瘤的分化良好。

HCC患者的肿瘤组织中检出HBV复制，代表肿瘤侵犯性较弱的亚型，具有转录组学特征。前基因组RNA（pgRNA）可作为病毒复制和患者预后的灵敏标志物。

原始出处：Boris Halgand, Christophe Desterke, Lise Rivière, et al. Hepatitis B Virus Pregenomic RNA in Hepatocellular Carcinoma: A Nosological and Prognostic Determinant. Hepatology(2017)

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2018-06-18 klivis

#HBV#

25 0
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2018-01-05 gwc384

#EPA#

37 0
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2018-01-05 ms7517674339485982

#GRN#

37 0
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2018-01-04 cscdliu

非常好.学习了

61 0
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2018-01-04 戒馋，懒，贪

谢谢分享学习了

58 0
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2018-01-04 1ddf0692m34(暂无匿称)

学习了.涨知识

59 0
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2018-01-04 忠诚向上

好好学习天天向上

48 0
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2018-01-04 Drhzm308

谢谢.学习了

54 0
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2018-01-04 1dd8c52fm63(暂无匿称)

了解了解.继续关注

21 0
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2018-01-04 yjs木玉

好好好好好好好好

19 0

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