PLoS One:牙周炎可增加复发性类风湿性关节炎的发病风险

2017-08-22 MedSci MedSci原创

本研究旨在评估牙周炎病史(PD)和复发性风湿症(PR)发生风险之间的关联。研究人员使用一个全国性的行政数据库,确定了2007年到2012年4421个新诊断的PR病例,然后根据性别、年龄和索引日期随机选择44210个非PR对照组(1:10)。校正合并症糖尿病后,使用条件Logistic回归分析评估比值比(OR)和95%可信区间(CI)来量化PD史和PR之间的关系。结果显示,PD史与PR之间存在关联(

本研究旨在评估牙周炎病史(PD)和复发性风湿症(PR)发生风险之间的关联。

研究人员使用一个全国性的行政数据库,确定了2007年到2012年4421个新诊断的PR病例,然后根据性别、年龄和索引日期随机选择44210个非PR对照组(1:10)。校正合并症糖尿病后,使用条件Logistic回归分析评估比值比(OR)和95%可信区间(CI)来量化PD史和PR之间的关系。

结果显示,PD史与PR之间存在关联(OR,1.51;95% CI,1.41-1.61)。PD定义变化后此关联仍明显相关。PD诊断最后时间与PR索引日期之间延迟时间越短以及PD就诊次数越多或PD相关就诊累及费用越大该关联的程度也就越大。排除569例索引日期后出现类风湿关节炎的PR患者后发现,PD和PR风险之间存在持续的时间和剂量依赖性关系。

总之,该研究结果表明,PD暴露与PR风险之间存在时间和剂量依赖性关系。

原始出处:

Ching-Heng Lin, Der-Yuan Chen, et al., Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. PLoS One. 2017; 12(8): e0182284. Published online 2017 Aug 3. doi: 10.1371/journal.pone.0182284.

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    2017-08-24 lmm397
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    2017-08-23 天涯183

    非常好的文章.学习了.很受益

    0

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    2017-08-23 龙胆草

    学习谢谢分享

    0

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    2017-08-23 130****4638

    学习了受益匪浅

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