J Endod:牙髓敏感性的影响因素分析:性别、心理变化、COMT基因和慢性面部疼痛

2018-03-22 lishiting MedSci原创

这篇研究的目的是为了评估牙髓敏感性的变化与性别因素、心理变化、编码酶儿茶酚-O-甲基转移酶(COMT)的基因以及慢性疼痛(颞颌关节病[TMDs])之间的联系。

这篇研究的目的是为了评估牙髓敏感性的变化与性别因素、心理变化、编码酶儿茶酚-O-甲基转移酶(COMT)的基因以及慢性疼痛(颞颌关节病[TMDs])之间的联系。研究包含97名受试者(68名女性、29名男性,年龄在20-44岁之间)。实验对受试者的下颌侧切牙实施电(电活力测试)和冷(冷冻剂喷雾)刺激。电活力刺激结果按照疼痛阈值表示(0-80 units),冷刺激结果按照疼痛强度评分表示(视觉数字量表,0-10)。TMD的研究用诊断标准用来评估TMD、抑郁和躯体症状。采用实时TaqMan法对从外周血提取的DNA进行3种COMT多态性(rs4680,rs6269和rs165774)的基因分型。采用多变量线性回归评估预测变量(临床和遗传)对牙髓敏感性(因变量)的联合影响。结果显示,电刺激的阈值反应与性别为女(P < .01)和rs165774多态性的纯合子GG基因型(P < .05)相关。冷刺激的疼痛强度在TMD患者中较高(P < .01),并且趋于在女性患者中多发。多变量线性回归分析显示,性别和rs165774 COMT多态性是电刺激疼痛敏感性的决定子,而TMD会导致冷刺激反

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    2019-01-05 jxrzshh
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    2018-03-22 飛歌

    学习了很有用

    0

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