美国科学家称肉毒杆菌剧毒毒素有转移风险

2016-08-23 佚名 新华社

注射肉毒杆菌是爱美人士抗皱紧肤的捷径。由于含有剧毒,肉毒杆菌毒素这种化学物质的应用一直倍受争议。美国科学家最近发现,肉毒杆菌毒素会向注射部位之外转移。美国威斯康星大学麦迪逊分校神经科学教授埃德温·查普曼及同事在培养皿中向小鼠神经细胞注射肉毒杆菌,结果发现肉毒杆菌毒素分子出现在未曾接受注射的神经细胞中。“每当一部分毒素局部(在其接触的第一个细胞)生效时,另一部分毒素即在别处起作用,”查普曼说,“目前

注射肉毒杆菌是爱美人士抗皱紧肤的捷径。由于含有剧毒,肉毒杆菌毒素这种化学物质的应用一直倍受争议。美国科学家最近发现,肉毒杆菌毒素会向注射部位之外转移。


美国威斯康星大学麦迪逊分校神经科学教授埃德温·查普曼及同事在培养皿中向小鼠神经细胞注射肉毒杆菌,结果发现肉毒杆菌毒素分子出现在未曾接受注射的神经细胞中。


“每当一部分毒素局部(在其接触的第一个细胞)生效时,另一部分毒素即在别处起作用,”查普曼说,“目前尚不清楚它们能移动多远,可能由注射剂量和其他因素决定。”他认为,如果能够基因改造肉毒杆菌所属的芽孢梭菌属细菌,就能准确控制肉毒杆菌毒素生效部位,不用担心其转移。“这是一个激动人心的前景,用更安全的药物取代市场价值20亿美元的药物”。研究结果刊登在最新一期《细胞报告》杂志中。


肉毒杆菌毒素会暂时麻痹神经,阻挠肌肉接收神经信号进行收缩,从而达到紧致肌肤的作用。这是一种剧毒物质,其使用剂量以万亿分之一克计量。美国食品和药物管理局2002年认为注射后其中毒素不会转移,批准了肉毒杆菌的临床使用,然而又在2009年警告了毒素转移风险。美国艾尔健公司出产的保妥适是目前市场占有率最高的肉毒杆菌注射产品,去年销量达到20亿美元。


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    2016-08-27 xmax889

    不要随便用药,用药有风险

    0

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    2016-08-24 1e0d99ddm02(暂无匿称)

    肉毒杆菌~~~这个研究课题风险性很大啊!

    0

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    2016-08-24 136****0753赵

    值得学习

    0

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    2016-08-24 老段

    关注一下风险问题

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