JAHA:血压升高对冠心病风险的增加存在累积效应

2020-07-07 MedSci原创 MedSci原创

高血压是心血管疾病发病率和死亡率的主要原因。然而,中年血压是否独立于晚年血压影响晚年心血管风险尚不清楚。

高血压是血管疾病发病率和死亡率的主要原因。然而,中年血压是否独立于晚年血压影响晚年心血管风险尚不清楚。

本研究采用单变量孟德尔随机化研究年龄≤55岁的遗传预测平均动脉压(MAP)对冠心病(CAD)风险的总体影响,并采用多变量孟德尔随机化方法,研究了年龄>55岁的遗传预测MAP调整后,遗传预测的MAP对冠心病风险的影响。在单变量和多变量的孟德尔随机化分析中,有一致的证据表明年龄≤55岁的高遗传预测的MAP增加了冠心病风险。经校正后,对于年龄≤55岁的遗传预测MAP增加10毫米汞柱,晚年CAD的风险比为1.43(95%CI,1.16-1.77;P=0.001)。

研究结果显示,血压升高对冠心病风险的增加存在终生累积效应。

原始出处:

Dipender G et al.Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis.JAHA.2020 July.

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    2020-08-26 lovetcm

    #血压#升高对#冠心病#风险的增加存在累积效应,近年来对趋势,累积效应的研究越来越多。以及血压升高多少,对风险的增加值,都值得关注

    0

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    2020-07-09 zhaohui6731
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    2020-07-07 为科研而奋斗

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