J Endod:吸烟者和不吸烟者牙髓中IL-1β, TNF-α, hBD-2和hBD-3的表达差异研究

2017-10-22 lishiting MedSci原创

到目前为止,还未有报道显示吸烟对牙髓中细胞因子和防御素的表达是否会产生影响。为此,这篇研究的目的是为了检测吸烟者牙髓中白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α, 人β防御素(hBD)-2和hBD-3的表达情况,并与未吸烟者进行对比。研究者推测:吸烟者牙髓中细胞因子和防御素的表达相对于不吸烟者来说会有所减少。

到目前为止,还未有报道显示吸烟对牙髓中细胞因子和防御素的表达是否会产生影响。为此,这篇研究的目的是为了检测吸烟者牙髓中白细胞介素(IL)-1β、肿瘤坏死因子(TNF)-α, 人β防御素(hBD)-2和hBD-3的表达情况,并与未吸烟者进行对比。研究者推测:吸烟者牙髓中细胞因子和防御素的表达相对于不吸烟者来说会有所减少。此横向研究选取了32名吸烟者和37名不吸烟者作为试验对象,其牙髓状态分别诊断为:正常、有症状的不可逆牙髓炎和无症状的不可逆牙髓炎。收集髓室样本并于-80°C保存于磷酸盐缓冲液中。使用Luminex检测IL-1β和TNF-α的表达水平,采用酶联免疫吸附测定法检测hBD-2和hBD-3的表达变化。标记物水平标准化为蛋白质浓度,并且通过Kruskal-Wallis检验, Mann-Whitney U检验和2-way方差分析对数据进行统计学处理(α = 0.05)。结果显示,吸烟者TNF-α和hBD-2在牙髓中的浓度明显降低(P < .01),而IL-1β或hBD-3的表达未发现显著性差异。2-way方差分析统计结果显示,吸烟状态对TNF-α和hBD-2的表达水平存在明显影

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    2017-10-27 jxrzshh
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    2017-10-24 snowpeakxu
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    2017-10-24 rgjl
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    2017-10-24 jjjiang0202
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    2017-10-22 惠映实验室

    学习了.谢谢.

    0

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