Int Arch Allergy Immunol:过敏性鼻炎中治疗前视觉模拟量表能够预测治疗结果么?

2020-02-21 AlexYang MedSci原创

剂治疗,共进行28天。研究发现,治疗前VAS评分与治疗前TNSSs(总鼻症状得分)和NMCCTs(鼻粘膜清除时间)呈现正相关关系(分别为ρ=0.66, p<0.001和r=0.44, p<0.001)。在治疗后,治疗前VAS评分与治疗后GSCs(整体症状控制)呈现负相关关系(r=-0.53, p<0.001)。TNSSs和NMCCTs的最小临床重要差异值(MCID)分别为3.19

视觉模拟量表(VAS)是评估过敏性鼻炎严重度的一种简单有用的工具。是否治疗前VAS评分能够指导合适的用药仍旧不清楚。

最近,有研究人员评估了是否治疗前VAS评分能够用于预测治疗响应。研究是一个为期4周的群体研究,包括了101名过敏性鼻炎患者。研究人员对所有患者进行每天220微克的曲安奈德水剂喷雾剂治疗,共进行28天。研究发现,治疗前VAS评分与治疗前TNSSs(总鼻症状得分)和NMCCTs(鼻粘膜清除时间)呈现正相关关系(分别为ρ=0.66, p<0.001和r=0.44, p<0.001)。在治疗后,治疗前VAS评分与治疗后GSCs(整体症状控制)呈现负相关关系(r=-0.53, p<0.001)。TNSSs和NMCCTs的最小临床重要差异值(MCID)分别为3.19和2.78。治疗前VAS截断值范围为6.5到7.7,均值为7.1。

最后,研究人员指出,治疗前VAS评分为7或者更高时与不良的治疗结果相关,表明了VAS评分具有潜在的治疗预测价值。

原始出处:

Kirtsreesakul V, Leelapong J, Ruttanaphol S et al. Can a Pretreatment Visual Analog Scale Predict Treatment Outcome in Allergic Rhinitis? Int Arch Allergy Immunol. 04 Feb 2020.

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    2020-02-23 膀胱癌
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    2020-02-23 zywlvao
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Int Forum Allergy Rhinol:过敏性鼻炎中TSLP和IL-33/ST2的协同作用以及组织缺氧作用研究

世界卫生组织(WHO)已经注明了过敏性疾病是21世纪的一个主要的健康问题。过敏性鼻炎(AR)是I型过敏性疾病,并通过鼻粘膜和免疫系统异常来进行鉴定。AR可以由各种炎症细胞来介导,并且具有细胞因子分泌改变的特征。胸腺基质淋巴生成素(TSLP)和白介素-33/刺激表达基因2 (IL-33/ST2)信号通路在许多炎症细胞响应和过敏性反应中具有重要的作用。在许多疾病中均报道了上述2个途径的互作关系。组织缺