JAMA Neurol:心血管疾病、大气污染与痴呆风险

2020-03-31 网络 网络

研究发现,长期暴露在空气污染下,患痴呆症的风险更高。心力衰竭和缺血性心脏病似乎增强了空气污染与痴呆之间的联系,而中风似乎是空气污染暴露与痴呆风险之间的重要中间条件

有证据表明,空气污染导致痴呆风险增加,近日研究人员考察了空气污染、心血管疾病(CVD)风险与痴呆的关系。
 
SNAC-K研究是在瑞典开展的,基于老龄化和护理的人群纵向研究。在斯德哥尔摩Kungsholmen地区随机抽取了5111名60岁或60岁以上、在家或机构生活的居民,排除521人。在符合资格的4590人中,评估了3363人(73.3%),其中2927名基线检查时无痴呆症参与者接受随访至2013年(平均[SD]随访时间,6.01?[2.56]年)。研究的主要终点为长期暴露于空气污染(PM2.5和氮氧化物)和痴呆之间的关系,并评估CVD(心房颤动、缺血性心脏病、心力衰竭和中风)在这种关联中的作用。
 
在基线检查时,2927名受试者的平均年龄为74.1岁,1845名(63.0%)为女性,共有364名发展为痴呆症患者。在过去5年里,居住地点的平均污染水平每增加25%,痴呆症的危险就增加多达50% (PM2.5水平增加0.88μg/m3,HR为1.54; 氮氧化物水平增加8.35 μg/m3 ,HR为1.14)。心力衰竭(PM2.5,HR :1.93;氮氧化合物,HR:1.43)和缺血性心脏病(PM2.5,HR:1.67;氮氧化合物HR:1.36)患者暴露于污染环境中导致痴呆风险进一步增加,而脑卒中似乎是最重要的条件,可解释49.4%的空气污染相关痴呆病例。
 
研究发现,长期暴露在空气污染下,患痴呆症的风险更高。心力衰竭和缺血性心脏病似乎增强了空气污染与痴呆之间的联系,而中风似乎是空气污染暴露与痴呆风险之间的重要中间条件。
 
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    2020-08-26 yinhl1978
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    2020-03-31 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2001008, encodeId=824e200100869, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Aug 26 20:28:49 CST 2020, time=2020-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316746, encodeId=95b41316e4680, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Apr 02 11:28:49 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472684, encodeId=c77114e2684f2, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Thu Apr 02 11:28:49 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498716, encodeId=3db71498e161d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Apr 02 11:28:49 CST 2020, time=2020-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036005, encodeId=41cb1036005a4, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Tue Mar 31 23:28:49 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048609, encodeId=d69e1048609f5, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Tue Mar 31 23:28:49 CST 2020, time=2020-03-31, status=1, ipAttribution=)]
    2020-03-31 junJUN

    老年人痴呆何药可用??

    0

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