Brit J Cancer:乳腺癌患者内乳链照射和蒽环类化疗后的心血管疾病发病率

2018-08-05 xing.T MedSci原创

由此可见,接受基于蒽环类化疗和接受大量平均心脏剂量暴露IMC照射的女性大大增加了几种CVD的发生率,筛查可能适合某些BC患者群体。

改善的乳腺癌(BC)存活率和展示了内乳淋巴结链(IMC)照射有益效果的证据强调了研究BC治疗晚期血管效应的重要性。

近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员评估了在1970-2009年期间接受治疗的14645名年龄<62岁的荷兰BC患者的血管疾病(CVD)发病率。该研究的分析包括比例风险模型和一般人群比较。

没有IMC的左右乳房照射的CVD率比为1.11(95%CI为0.93-1.32)。与仅右侧乳房照射相比,IMC照射(平均心脏剂量四分位间距为9-17 Gy)与整体CVD、缺血性心脏病(IHD)、心力衰竭(HF)和心脏瓣膜病发生率增加有关(风险比(HRs):1.6-2.4)。治疗后,IHD风险增加至少持续20年。基于蒽环类的化疗与HF发生率增加有关(HR=4.18,95%CI为3.07-5.69),并且在治疗后5年内发生,至少10-15年仍然增加。与IMC照射和基于蒽环类的化疗相比,IMC照射与蒽环类化疗联合治疗与HF发生率显著增加相关(HR=9.23 95%CI为6.01-14.18)。

由此可见,接受基于蒽环类化疗和接受大量平均心脏剂量暴露IMC照射的女性大大增加了几种CVD的发生率,筛查可能适合某些BC患者群体。

原始出处:

Naomi B. Boekel,et al. Cardiovascular disease incidence after internal mammary chain irradiation and anthracycline-based chemotherapy for breast cancer.British Journal of Cancer. 2018. https://www.nature.com/articles/s41416-018-0159-x

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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-20 wqkm

    ^_^^_^^_^^_^

    0

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10:25:47 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337500, encodeId=01bb33e50051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Thu Aug 09 09:33:26 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571136, encodeId=9a1115e11367c, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Tue Aug 07 07:33:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521702, encodeId=eb7f1521e0248, content=<a href='/topic/show?id=a59d88340d2' target=_blank style='color:#2F92EE;'>#蒽环类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88340, encryptionId=a59d88340d2, topicName=蒽环类)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97d111387900, createdName=shijzhiewnjhch, createdTime=Tue Aug 07 07:33:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498450, encodeId=a6691498450ee, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Aug 07 07:33:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336939, encodeId=421c336939c5, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Tue Aug 07 01:03:49 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336925, encodeId=d44c33692510, content=不错的文章,值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-16 xzsz3344

    谢谢分享

    0

  5. 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10:25:47 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337500, encodeId=01bb33e50051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Thu Aug 09 09:33:26 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571136, encodeId=9a1115e11367c, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Aug 07 07:33:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336939, encodeId=421c336939c5, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Tue Aug 07 01:03:49 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336925, encodeId=d44c33692510, content=不错的文章,值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-09 衣带渐宽

    学习

    0

  6. 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10:25:47 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337500, encodeId=01bb33e50051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Thu Aug 09 09:33:26 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571136, encodeId=9a1115e11367c, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
  7. 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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
  8. 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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
  9. 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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-07 phoebeyan520

    学习了,谢谢分享

    0

  10. 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createdName=131****2916, createdTime=Mon Aug 06 23:31:11 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-06 131****2916

    不错的文章,值得推荐

    0

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