Eur J Gastroenterol Hepatol:患有非酒精性肝病的糖尿病患者,其心血管疾病的风险增加

2018-05-29 MedSci MedSci原创

这是独立于DM的影响,最先研究NAFLD与CVD之间关系的荟萃分析。研究结果表明,NAFLD增加了具有类似DM的人群的CVD的风险。诊断为NAFLD的糖尿病患者可能受益于更早期的心血管风险评估,从而降低心血管疾病的发病率和死亡率。

研究背景:非酒精性脂肪肝(NAFLD)与心血管疾病(CVD)的风险增加有关。此荟萃分析定量评估了NAFLD和CVD在糖尿病患者中的相关性。

研究方法:研究分析了PubMed、EMBASE和Cochrane图书馆数据库中的相关数据,时间截止为2017年3月。纳入在糖尿病人群中,分析NAFLD和心血管危险因素相关性的原始研究。利用随机效应模型提取了与结果相关的可用数据。采用Newcastle-Ottawa质量评估量表评估纳入荟萃分析中的研究的质量。

研究结果:在最初确定的770项研究中,最终有11项(涉及8346例患者)研究被纳入到此荟萃分析中。Newcastle-Ottawa质量评估量表得分表明,这些研究为高质量研究。联合效应估计显示,与没有NAFLD的患者相比,NAFLD患者的CVD风险增加了2倍(优势比=2.20,95%置信区间:1.67-2.90)。横断面研究、队列研究中都表明,NAFLD患者的CVD风险显著增加,优势比分别为2.28 (1.61-3.23)和1.90 (1.48-2.45)。

研究结论:这是独立于DM的影响,最先研究NAFLD与CVD之间关系的荟萃分析。研究结果表明,NAFLD增加了具有类似DM的人群的CVD的风险。诊断为NAFLD的糖尿病患者可能受益于更早期的心血管风险评估,从而降低心血管疾病的发病率和死亡率。

原始出处:

Zhou YY, Zhou XD, Wu SJ, et al. Synergistic increase in cardiovascular risk in diabetes mellitus with nonalcoholic fatty liver disease: a meta-analysis.Eur J Gastroenterol Hepatol, 2018, 30(6), 631-636.

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    2019-01-12 许安
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createdName=andy2090, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319902, encodeId=069c31990287, content=学习了.有用的研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed May 30 07:43:38 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1676409, encodeId=382c16e6409f6, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Thu Sep 06 05:34:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673402, encodeId=765e16e340295, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, 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style='color:#2F92EE;'>#酒精性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95484, encryptionId=63ad95484f9, topicName=酒精性肝病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f2c2500194, createdName=446798725_87912765, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427127, encodeId=e04a142e12771, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), 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createdName=andy2090, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319902, encodeId=069c31990287, content=学习了.有用的研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed May 30 07:43:38 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
  6. 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style='color:#2F92EE;'>#酒精性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95484, encryptionId=63ad95484f9, topicName=酒精性肝病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f2c2500194, createdName=446798725_87912765, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427127, encodeId=e04a142e12771, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), 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createdName=andy2090, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319902, encodeId=069c31990287, content=学习了.有用的研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed May 30 07:43:38 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
  7. 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style='color:#2F92EE;'>#酒精性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95484, encryptionId=63ad95484f9, topicName=酒精性肝病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f2c2500194, createdName=446798725_87912765, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427127, encodeId=e04a142e12771, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), 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createdName=andy2090, createdTime=Thu May 31 12:34:00 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319902, encodeId=069c31990287, content=学习了.有用的研究成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Wed May 30 07:43:38 CST 2018, time=2018-05-30, status=1, ipAttribution=)]
    2018-05-31 gwc384
  8. 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    2018-05-30 明崖

    学习了.有用的研究成果

    0

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