JPEN: 小儿肝移植后肌肉减少症的持续存在与较差的生长和反复住院相关

2019-03-09 不详 MedSci原创

肌肉减少症在成人肝移植前(LTx)和LTx后普遍存在,均会导致不良临床后果。而目前关于小儿LTx患者的肌肉减少症患病率还没有文献进行报道。因此,本项研究这项旨在探究儿童LTx受试者的肌肉减少症患病率及其与LTX后生长和医疗保健利用的关系。

介绍
肌肉减少症在成人肝移植前(LTx)和LTx后普遍存在,均会导致不良临床后果。而目前关于小儿LTx患者的肌肉减少症患病率还没有文献进行报道。因此,本项研究这项旨在探究儿童LTx受试者的肌肉减少症患病率及其与LTX后生长和医疗保健利用的关系。

方法
研究人员通过双能量X射线吸收测定法对58名儿童进行前瞻性评估(测量指标:绝对/区域/脂肪质量百分比[FM],无脂肪质量[FFM],骨骼肌质量[SMM])。肌肉减少症被定义为SMM z评分≤2。对儿童的生长发育指标以及住院时间长度(总体,重症监护病房[ICU],紧急情况,再入院)和呼吸机依赖性进行了分析。

结果
肌肉减少症的发生率总体为29%(n = 17); LTx后发生肌肉减少症的平均时间为1.1±1.9(1-8)年。≤9.8岁的女性儿童的肌肉减少症患病率高于> 9.8岁的儿童(83.1%对17.1%; p = 0.004)。肌肉减少症与较低的体重速度标准差评分相关,LTx后2-10年体重z /身高z评分较低,住院治疗(总体,ICU,急诊和再入院)和呼吸机依赖性增加(p <0.05)。

结论
这项研究显示肌肉减少症与LTx后儿童的较差生长和复发住院相关。

原始出处:

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    2019-11-08 feather89
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