Hum Reprod Update:生殖障碍的女性拥有更高的不良妊娠结局

2015-12-24 MedSci MedSci原创

背景:生殖障碍和不孕与产科的并发症有相关性,而且对妊娠的结局有负面影响。受影响的患者常常需要借助辅助生殖技术(ART)受孕,高龄产妇的年龄也是进一步的混杂因素。目前的挑战则是剖析因果关系,即决定不孕不育和生殖疾病如何单独或共同影响女性不良妊娠结局,研究其中的相关和混杂因素。方法:检索PubMed上已发表的截止2015年6月的文章,总结所有关于不孕、有生殖障碍的女性的围产儿结局和影响不良妊娠结局的潜

背景:生殖障碍和不孕与产科的并发症有相关性,而且对妊娠的结局有负面影响。受影响的患者常常需要借助辅助生殖技术(ART)受孕,高龄产妇的年龄也是进一步的混杂因素。目前的挑战则是剖析因果关系,即决定不孕不育和生殖疾病如何单独或共同影响女性不良妊娠结局,研究其中的相关和混杂因素。

方法:检索PubMed上已发表的截止2015年6月的文章,总结所有关于不孕、有生殖障碍的女性的围产儿结局和影响不良妊娠结局的潜在机制的证据。

结果:生殖障碍(子宫内膜异位症、多囊卵巢综合征)和不明原因的不孕症共享炎症通路、内分泌异常、蜕膜的衰老和血管异常,这也许会通过共同的机制影响妊娠的成功率。无论是单独还是联合,这些障碍导致早产的风险增加、胎儿成长受限、胎盘疾病和高血压。全身性激素异常、炎症和影响子宫内膜、子宫肌层、宫颈和胎盘的代谢因素与着床和妊娠期间的异常环境有相关性,由此引发产科并发症的发生。这些特征中的一部分已经记录在ART的胎盘部分中。

结论:生殖障碍通常发生在女性的育龄期间,很少是独立存在的。这些障碍具有的相关性炎症、内分泌和代谢机制使产科并发症的发生率增加。这些患者应该意识到不良妊娠结局的高风险,并且应以专业的跟踪检测后续情况。日后需要基于有关临床管理和专业产科护理路径的指南发展,以做出及时的预防性治疗措施。

原始出处:


Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, Petraglia F.Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome.Hum Reprod Update. 2016 Jan;22(1):104-15

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1796609, encodeId=64c91e9660967, content=<a href='/topic/show?id=6f28181514b' target=_blank style='color:#2F92EE;'>#Update#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18151, encryptionId=6f28181514b, topicName=Update)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Fri Aug 19 06:11:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50122, encodeId=5d845012251, content=很有道理!, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6dc1665697, createdName=xi.xiong, createdTime=Tue Dec 29 09:05:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50115, encodeId=717a5011571, content=能不能把pmic, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Tue Dec 29 08:23:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49723, encodeId=f6c649e23a0, content=很值得好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 23:17:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47905, encodeId=30304e90558, content=很有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 10:49:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392909, encodeId=b09b1392909e3, content=<a href='/topic/show?id=8c9f4492370' target=_blank style='color:#2F92EE;'>#妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44923, encryptionId=8c9f4492370, topicName=妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Sat Dec 26 02:11:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469446, encodeId=103f1469446ea, content=<a href='/topic/show?id=850120501c5' target=_blank style='color:#2F92EE;'>#不良妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20501, encryptionId=850120501c5, topicName=不良妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa987034131, createdName=cmsvly, createdTime=Sat Dec 26 02:11:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601781, encodeId=e3421601e816b, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Dec 26 02:11:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2015-12-29 xi.xiong

    很有道理!

    0

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    2015-12-29 cmn

    能不能把pmic

    0

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    2015-12-27 忠诚向上

    很值得好学习

    0

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    2015-12-26 hixiaoluo

    很有道理

    0

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    2015-12-26 仁者大医

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