日本科学家小保方晴子是不是被冤枉了?

2016-02-04 佚名 中新网

瑞士洛桑联邦理工学院(EPFL)的科学家开发出了一种方法,可以通过“挤压”细胞使其转变成为干细胞,该方法为大规模生产干细胞用于医学目的提供了新的思路,相关研究发表于国际杂志2016年1月11日的《自然材料》(Nature Materials)上。这条近日发布的科学新闻可能不会引起人们太多的关注,因为科学的深奥让公众一般对其敬而远之,而且有关干细胞研究的成果或结果可谓过江之鲫,没法吸引眼球。不过,如

瑞士洛桑联邦理工学院(EPFL)的科学家开发出了一种方法,可以通过“挤压”细胞使其转变成为干细胞,该方法为大规模生产干细胞用于医学目的提供了新的思路,相关研究发表于国际杂志2016年1月11日的《自然材料》(Nature Materials)上(见报道:Nat Mater:“挤压”细胞让其转化成为干细胞)。

这条近日发布的科学新闻可能不会引起人们太多的关注,因为科学的深奥让公众一般对其敬而远之,而且有关干细胞研究的成果或结果可谓过江之鲫,没法吸引眼球。

不过,如果提到日本“美女科学家”小保方晴子,就不会对这条消息置若罔闻,或视而不见。这个消息至少可以提出一些问题,科学或工作的目标是否可以条条道路通罗马?小保方晴子是否被冤枉了?



2014年1月29日,日本理化研究所发育生物学中心年仅30岁的女科学家小保方晴子领衔的研究团队在英国《自然》杂志上同时在线发表了两篇关于“刺激触发多能性获得”(STAP)的论文,提出酸浴(把细胞浸泡在酸性溶液中)和挤压等方式可以更为简便地培养出多能细胞(又称万能细胞),即STAP细胞,这种细胞被视为类似诱导的多能干细胞。

但是,小保方晴子的研究结果随即遭到国际科学界的质疑,因为,除了小保方晴子的团队,其他任何人按照其文章提供的方法都不能重复出他们的实验结果。这有违一项科学研究的结果和事实在相同和相似环境与条件下可以重复的原则(科赫原则)。小保方晴子所在的单位日本理化学研究所组织研究人员进行调查,在2015年9月23日的《自然》杂志上发表文章称,小保方晴子的研究结果是“STAP细胞为混入胚胎干细胞(ES细胞)的结果”。

小保方晴子身败名裂,不仅丢掉了工作(从原单位辞职),还于2015年11月2日被早稻田大学取消其以前获得的博士学位。此外,受到牵连的小保方晴子的导师笹井芳树自杀。尽管受到这些重创,但小保方晴子一直坚持,STAP细胞具有真实性,STAP细胞制备方法的论文是正确的,其自杀的导师笹井芳树也在遗书中嘱咐小保方晴子“一定要再现STAP细胞啊”……

现在,尽管小保方晴子还没有再现STAP细胞,但瑞士研究人员的研究结果似乎在支持小保方晴子此前的研究结果。对于细胞重新编程产生诱导的多能干细胞,相当多的研究人员认为,物理和化学的多种方法都可以影响和促成这类干细胞的形成。挤压这种简单(实则并不简单)的方式同样可以影响和促成干细胞的生成。

瑞士的研究人员采用物理挤压的方法把成体细胞诱导为干细胞,这种突破显然比小保方晴子此前的酸处理和挤压方式更简单,结果也更惊人。结果的突破源于认知的突破。过去研究人员对干细胞的传统培育方法是利用细胞培养皿或细胞培养瓶等二维方法来进行。但是,机体的细胞是在三维环境中生存的。因此,瑞士研究人员研发了一种新方法来模拟三维环境的细胞培养,这就是一种特殊的凝胶。把正常细胞置于包含正常生长营养物质的特殊凝胶中,就可以达到模拟活体组织中的三维环境。

通过调整干细胞周围凝胶的组成(硬度和密度),凝胶就会对细胞行使驱动力,通过“挤压”来使其转变成为干细胞,因为这种方式和过程可以对细胞进行快速而且有效的重编程。三维环境可以产生机械性信号,并且同特殊的遗传因子相互作用从而使得细胞更加容易地转变成为干细胞。

小保方晴子的研究思路显然与瑞士研究人员是一致或相似的,因为在研究中小保方晴子发现,细胞在经过各种处理后会表现出类似干细胞的表现,这些处理方式包括加热、酸处理和挤压等,最后发现用酸处理和挤压效果比较好,能让成体细胞转变为与诱导的多能干细胞相似的STAP细胞。

挤压让细胞重编程产生干细胞的原理似乎简单,但是,操作起来并不那么容易,所以,以小保方晴子介绍的相同方式,其他研究人员并未能得到重复的研究结果。现在,瑞士研究人员的结果似乎重复了小保方晴子的研究结果。但是,谁又能重复瑞士研究人员的这一研究结果呢?

于是,问题的结局有两个。一是有更多的研究团队来重复瑞士研究人员的研究结果,并因此而为小保方晴子洗冤。另一个结果是,后续的多项研究并不能重复瑞士研究人员的挤压产生干细胞的结果,也因此又有可能是类似小保方晴子的结局。

看来,好戏才刚刚开始。不过,这揭示了科学的本质,在多重质疑和反复中,对事物本质和真相的认识是从相对真理到无限接近绝对真理的慢慢靠近。

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    2016-03-01 wushaoling
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23:23:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63276, encodeId=e67a632e667, content=有些伪科学被崇,真理却被埋没。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Thu Feb 04 22:06:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63267, encodeId=18a26326e67, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63268, encodeId=7015632687a, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63265, encodeId=85b56326507, content=科学的道路上也会有流血牺牲, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-04-09 lyh994

    科学研究定义本身就有时代认识的局限性,所以很多所谓的伪科学,后来都光宗耀祖了

    0

  4. 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  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-05 老段

    好的

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-04 vinson820801

    当年这个丑闻很轰动的

    0

  7. 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createdBy=df2b38746341, createdName=wushaoling, createdTime=Tue Mar 01 09:05:00 CST 2016, time=2016-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76569, encodeId=1570e65698b, content=科学研究定义本身就有时代认识的局限性,所以很多所谓的伪科学,后来都光宗耀祖了, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Apr 09 09:10:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294231, encodeId=f50112942317c, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Feb 06 06:05:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63320, encodeId=85da6332092, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Feb 05 09:15:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63286, encodeId=48a66328640, content=当年这个丑闻很轰动的, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Thu Feb 04 23:23:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63276, encodeId=e67a632e667, content=有些伪科学被崇,真理却被埋没。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Thu Feb 04 22:06:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63267, encodeId=18a26326e67, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63268, encodeId=7015632687a, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63265, encodeId=85b56326507, content=科学的道路上也会有流血牺牲, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-04 sword20000

    有些伪科学被崇,真理却被埋没。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1709321, encodeId=643d1e0932158, content=<a href='/topic/show?id=3df6468696b' target=_blank style='color:#2F92EE;'>#小保方晴子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46869, encryptionId=3df6468696b, topicName=小保方晴子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Aug 27 14:05:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775015, encodeId=8ff21e7501541, content=<a href='/topic/show?id=5e9a6094488' target=_blank style='color:#2F92EE;'>#本科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60944, encryptionId=5e9a6094488, topicName=本科)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Feb 06 06:05:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63320, encodeId=85da6332092, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Feb 05 09:15:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63286, encodeId=48a66328640, content=当年这个丑闻很轰动的, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Thu Feb 04 23:23:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63276, encodeId=e67a632e667, content=有些伪科学被崇,真理却被埋没。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Thu Feb 04 22:06:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63267, encodeId=18a26326e67, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63268, encodeId=7015632687a, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63265, encodeId=85b56326507, content=科学的道路上也会有流血牺牲, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-04 ssummer

    科学进步也很残酷!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1709321, encodeId=643d1e0932158, content=<a href='/topic/show?id=3df6468696b' target=_blank style='color:#2F92EE;'>#小保方晴子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46869, encryptionId=3df6468696b, topicName=小保方晴子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sat Aug 27 14:05:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775015, encodeId=8ff21e7501541, content=<a href='/topic/show?id=5e9a6094488' target=_blank style='color:#2F92EE;'>#本科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60944, encryptionId=5e9a6094488, topicName=本科)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Feb 06 06:05:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63320, encodeId=85da6332092, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Feb 05 09:15:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63286, encodeId=48a66328640, content=当年这个丑闻很轰动的, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Thu Feb 04 23:23:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63276, encodeId=e67a632e667, content=有些伪科学被崇,真理却被埋没。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Thu Feb 04 22:06:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63267, encodeId=18a26326e67, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63268, encodeId=7015632687a, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Thu Feb 04 21:50:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63265, encodeId=85b56326507, content=科学的道路上也会有流血牺牲, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-04 ssummer

    科学进步也很残酷!

    0

  10. 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encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Feb 06 06:05:00 CST 2016, time=2016-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63320, encodeId=85da6332092, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Feb 05 09:15:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63286, encodeId=48a66328640, content=当年这个丑闻很轰动的, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5b91683812, createdName=vinson820801, createdTime=Thu Feb 04 23:23:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63276, encodeId=e67a632e667, content=有些伪科学被崇,真理却被埋没。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLAibgOibuZnfdFE64hJHibbD6WwEgyaXx7DtibMOSicJ6JZoLEAIdAdkhDmHWO7P7OXg2tkTicZy9libryicw/0, createdBy=aa991670466, createdName=sword20000, createdTime=Thu Feb 04 22:06:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=63267, encodeId=18a26326e67, content=科学进步也很残酷!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Thu Feb 04 21:09:00 CST 2016, time=2016-02-04, status=1, ipAttribution=)]
    2016-02-04 pangshiwei

    科学的道路上也会有流血牺牲

    0

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近日,一篇刊登在国际著名杂志Cell上的研究报道中,来自新加坡A*STAR基因组研究所的研究人员通过研究首次揭示细胞周期时钟控制多能干细胞分化的分子机制,相关研究或为理解细胞分化机制,以及开发新型潜在疗法提供思路。胚胎干细胞并不能分化为特殊类型的细胞,当其出于多能性状态时才可以,细胞周期分为四个阶段:G1、S、G2及M期,此前有研究发现胚胎干细胞的细胞分化尽在G1期才开始,而由于G1期的特性才会

NCB:靶向代谢酶可维持胚胎干细胞原始态

                最近一项研究表明,细胞代谢产物改变能够调节生命最早期阶段的胚胎干细胞发育。这项研究将帮助科学家提高应用胚胎干细胞获得新组织和新器官的能力,同时也会促进不孕不育以及癌症等常见病治疗方法的开发。   相关研究结果发表在国际学术期刊Nature Cell Biology

Nature:规范胚胎干细胞研究

目前,已有3个独立的研究团队使用克隆技术制备出人胚胎干细胞。首个利用婴儿和胎儿细胞构建克隆胚胎的成果在去年被公开。而在过去的几月间,又有2例类似的研究被报道——作为细胞供体的分别是一名75岁的男性和一名患有I型糖尿病的32岁女性。 目前,胚胎克隆和构建干细胞研究主要是利用成年人的细胞,研究成果被用于对某一特定个体进行治疗。用于实验的人类胚胎会被更多的构建已是既定事实。因此,我们需要更为完善

Lancet:胚胎干细胞首次被证实可用来治疗人类疾病

9月初,日本理化研究所(RIKEN)发育生物学中心的眼科专家高桥雅代使用诱导多能干细胞(iPS)治疗与年龄相关的视网膜退化疾病。近日,来自美国Advanced Cell Technology公司首席技术官Robert Lanza在Lancet杂志发表文章称,通过中长期的观察发现,胚胎干细胞治疗人体疾病是安全、有效的,这也是首个对胚胎干细胞治疗效果进行研究的报告。该研究有望加快干细胞在疾病治疗领

Cell:科学家首次使得人类干细胞成功复位至原始状

近日,来自欧洲分子生物学室验室等处的研究人员解决了一个干细胞生物学领域长期以来的一大难题,研究者成功地将人类多能性干细胞成功回复到了最原始的状态,相关研究研究成果发表在国际杂志Cell上。机体早期发育的胚胎干细胞,其可以分化成为任何类型的细胞;截至目前科学家们仅仅可以将人类成体干细胞转化成为含有不同特性的多能性干细胞,进而使其分化成为特定类型的细胞;Paul Bertone博士表示,将小鼠细胞转变

Stem Cell Rep:科学家利用小鼠胚胎干细胞首次在体外成功构建了3D脊髓组织

脊椎动物的神经系统源于神经管的发育所成,而神经管则是脊椎动物脊髓和大脑分化的基础,近日,来自德国德累斯顿工业大学等处的研究人员通过研究首次实现了利用小鼠胚胎干细胞在体外成功构建了三维的脊髓结构,相关研究成果刊登于国际杂志Stem Cell Reports上。 很多年以来研究人员一直致力于在分子水平上研究墨西哥蝾螈的再生潜力,机体损伤后墨西哥蝾螈可以实现脊髓和其它器官的再生而且再生后的组织具有