Tumour Biol:RUNX2转录因子在非小细胞肺癌肺上皮细胞间质转化中的作用

2019-05-25 不详 网络

肺癌在全世界男性和女性中的死亡率很高。大约15%的这类癌症患者的诊断率不超过5年生存率。不幸的是,诊断常在癌症晚期,其他组织或器官可能受到影响。近年来,谱系特异性转录因子与多种癌症相关。可能调节癌症的一种这样的转录因子是RUNX2,它是早期和晚期成骨的主基因。在甲状腺和前列腺癌中,据报道RUNX2调节肿瘤细胞迁移和侵袭中重要基因的表达。在本研究中,我们报道了16例原发性非小细胞肺癌和/或与P1K基

肺癌在全世界男性和女性中的死亡率很高。大约15%的这类癌症患者的诊断率不超过5年生存率。不幸的是,诊断常在癌症晚期,其他组织或器官可能受到影响。近年来,谱系特异性转录因子与多种癌症相关。可能调节癌症的一种这样的转录因子是RUNX2,它是早期和晚期成骨的主基因。在甲状腺和前列腺癌中,据报道RUNX2调节肿瘤细胞迁移和侵袭中重要基因的表达。

在本研究中,我们报道了16例原发性非小细胞肺癌和/或与P1K基因启动子区H3K27Ac相关的转移性肺癌患者的RUNX2/p57过度表达。在一些患者中,除了WDR5,MLL2,MLL4和UTX酶募集之外,还检测到H3K4Me3富集,COMPASS-LIKE复合物的成员。此外,转化生长因子-β诱导的RUNX2/p57过表达和特异性RUNX2敲低支持RUNX2在上皮间充质转换中的作用,这通过在腺癌A549肺癌细胞系中丧失功能测定来证明。此外,RUNX2增加上皮间充质转换基因VIMENTIN,TWIST1和SNAIL1的表达,这反映了肺腺癌细胞中迁移能力的增加。

原始出处:

Herreño AM, Ramírez AC, et al., Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter. Tumour Biol. 2019 May;41(5):1010428319851014. doi: 10.1177/1010428319851014.

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    2019-10-22 sunylz
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    2020-02-05 mjldent
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    2020-05-03 柳叶一刀
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    2019-09-29 stfoxst
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