Circulation:暴发性心肌炎与急性非暴发性心肌炎的生存率和左心功能改变

2017-06-05 xiangting MedSci原创

与NFM相比,FM的死亡率和HTx需求高。从功能学角度看,FM在入院时LVEF受损更重,尽管住院期间急剧改善,长期随访中仍低于NFM。

此前的报道表明尽管有更急性的临床表现,暴发性心肌炎(FM)患者的预后可能比急性非暴发性心肌炎(NFM)更好。在这项回顾性研究中分析了与NFM相比, FM患者队列的结局和左室射血分数(LVEF)的改变。

研究人群包括2001年5月至2016年11月期间诊断为急性心肌炎(症状发作<1个月)而入院的187例患者,其中55例需要肌力和/或机械循环支持(FM),而其余132例血流动力学稳定(NFM)。此外研究人员还对130例成年急性病毒性心肌炎和发病2周内有病毒感染前驱症状的患者进行了亚分析,其中包括34例FM与96例NFM。巨细胞、嗜酸性细胞心肌炎或心脏结节病和15岁以下的受试者被排除在后面的亚分析之外。

在整个人群(n = 187)中,住院死亡或心脏移植(HTx)在FM与NFM分别为25.5%、0%(p<0.0001)。FM的9年长期无HTx生存率低于NFM(64.5%vs. 100%,Log Rank p<0.0001)。尽管FM住院期间LVEF比NFM有更大改善(中位数为32%,四分位数:20-40%vs.3%,0-10%。p<0.0001),最后随访时FM中LVEF <55%的患者比例高于NFM(29%vs. 9%,相对风险3.32,95%置信区间:1.45-7.64,p=0.003)。在病毒性心肌炎的亚组中(n=130)观察到关于FM与NFM生存率和LVEF改变的相似结果。在随访期间,NFM和出院时LVEF≥55%的患者均无LVEF的显著性下降。

与NFM相比,FM的死亡率和HTx需求高。从功能学角度看,FM在入院时LVEF受损更重,尽管住院期间急剧改善,长期随访中仍低于NFM。这些发现也适用于仅考虑病毒形式,并与以前显示FM预后更好的研究不同。

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    2017-06-05 changjiu

    学习了,谢谢

    0

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    2017-06-05 楠博One

    感冒是罪魁祸首

    0

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    2017-06-05 Y—xianghai

    学习了新知识

    0