Sci Rep:PLAGL2在膀胱上皮恶性肿瘤中的表达和它与淋巴结转移和生存的关系研究

2018-04-28 AlexYang MedSci原创

最近,有研究人员调查了PLAGL2的表达与病理特征及预后和在膀胱上皮恶性肿瘤(BUC)中的淋巴结转移预测的相关性。研究人员搜集了根治性切除后,203名患有膀胱上皮恶性肿瘤患者的病理活检样本和临床数据。PLAGL2的表达通过免疫组化染色来进行检测。研究人员还分析了对淋巴结转移和BUC患者的预后进行了分析。研究发现,PLAGL2在BUC中和阳性淋巴结中的表达要显著更高与正常膀胱组织(89.06%和 7

最近,有研究人员调查了PLAGL2的表达与病理特征及预后和在膀胱上皮恶性肿瘤(BUC)中的淋巴结转移预测的相关性。研究人员搜集了根治性切除后,203名患有膀胱上皮恶性肿瘤患者的病理活检样本和临床数据。PLAGL2的表达通过免疫组化染色来进行检测。研究人员还分析了对淋巴结转移和BUC患者的预后进行了分析。

研究发现,PLAGL2在BUC中和阳性淋巴结中的表达要显著更高与正常膀胱组织(89.06%和 76.56% vs 21.88%, P<0.001)。逻辑回归分析表明PLAGL2的表达是BUC淋巴结转移的 一个独立风险因子(P<0.05)。COX比例风险回归模型表明了复发的时间和总生存在PLAGL2过表达的患者中要比那些低表达的患者显著更少(P<0.05)。另外,相对于正常膀胱组织,PLAGL2在BUC组织和转移性淋巴结中高度表达。上述表达与肿瘤大小和数据以及肿瘤等级和阶段相关。PLAGL2的过表达能够成为淋巴结转移和病人生存的一个独立预测因子。

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    2018-04-30 sodoo
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    2018-04-29 kafei

    了解一下谢谢

    0

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    2018-04-28 有备才能无患

    最近.有研究人员调查了PLAGL2的表达与病理特征及预后和在膀胱上皮恶性肿瘤(BUC)中的淋巴结转移预测的相关性.研究人员搜集了根治性切除后.203名患有膀胱上皮恶性肿瘤患者的病理活检样本和临床数据.PLAGL2的表达通过免疫组化染色来进行检测.研究人员还分析了对淋巴结转移和BUC患者的预后进行了分析.

    0

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    2018-04-28 wqkm

    ^_^^_^^_^^_^

    0

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    2018-04-28 天地飞扬

    了解一下.谢谢分享!

    0

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    2018-04-28 orangesking

    .....

    0

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血清相关抗原5(SPAG5)参与了多种生物学过程。然而,SPAG5在膀胱上皮恶性肿瘤(BUC)中的角色仍旧未知。最近,在112名经历了根治性膀胱切除术患者中,有研究人员展示了SPAG5的上调在原发性BUC组织中经常检测到,并且与显著更差的生存相关。研究发现,SPAG5表达的上调或者下调能够分别增强或者抑制BUC细胞在体外和体内的增殖。更多的是,SPAG5能够增加BUC细胞对化疗诱导细胞凋亡作用的抗