Chest:阿托伐他汀治疗铜绿假单胞菌感染的支气管扩张患者疗效如何?

2017-06-03 xing.T MedSci原创

由此可见,该研究结果表明阿托伐他汀可以降低感染铜绿假单胞菌的支气管扩张患者全身炎症和改善生活质量。这些效应可能是由于阿托伐他汀调节中性粒细胞活化能力所致。

在重症支气管扩张、慢性铜绿假单胞菌感染的患者中,尚没有采用他汀类药物治疗的随机对照试验(RCT)。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员将32例慢性铜绿假单胞菌感染患者招募入双盲交叉RCT中。每个队列中招募了16例患者,分别给予80mg阿托伐他汀或安慰剂治疗3个月,接下来进行6周的洗脱期,进行交叉并给予替代治疗3个月。

共有27例患者完成了研究治疗 。阿托伐他汀没有明显改善通过莱斯特咳嗽问卷测量的咳嗽这一主要终点[平均差异为1.92,95%可信区间为(-0.57至4.41),P=0.12]。然而,阿托伐他汀治疗可改善圣乔治呼吸疾病问卷(-5.62分,P=0.016),降低血清CXCL8(P=0.04)、肿瘤坏死因子(P=0.01)和细胞间粘附分子-1(P=0.04)的水平。具有改善血清CRP与血清中性粒细胞计数(分别有P=0.07和P=0.06)的趋势。在体外实验中,研究人员发现10μM的阿托伐他汀可以减少fMLF诱导的CD11b表达上调和反映降低中性粒细胞激活能力降低的钙流变化。

由此可见,该研究结果表明阿托伐他汀可以降低感染铜绿假单胞菌的支气管扩张患者全身炎症和改善生活质量。这些效应可能是由于阿托伐他汀调节中性粒细胞活化能力所致。

原始出处:


Pallavi Bedi,et al. A randomised control trial of atorvastatin in bronchiectasis patients infected with Pseudomonas aeruginosa- a proof of concept study.chest.2017. http://journal.publications.chestnet.org/article.aspx?articleid=2630498

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    2018-04-06 Smile2680
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ad01994393, createdName=溜溜梅不酸, createdTime=Sun Jun 04 09:11:52 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206210, encodeId=c1a820621063, content=学习了,提高了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Sun Jun 04 06:25:40 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206161, encodeId=40da2061611a, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-12-27 lsj637
  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-04 cqykthl

    真是大开眼界啦!

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-04 溜溜梅不酸

    还阿托伐他汀钙还有这种作用,对它的药理作用需要再看看

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-04 杨利洪

    学习了,提高了

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 04 00:25:43 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206150, encodeId=f0d020615025, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Jun 03 23:50:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206097, encodeId=a1a920609e99, content=一药多用,非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-04 tanxingdoctor

    学习啦谢谢分享

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jun 04 00:25:43 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206150, encodeId=f0d020615025, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Jun 03 23:50:25 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206097, encodeId=a1a920609e99, content=一药多用,非常好, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 天涯183

    非常好的文章,学习了,很受益

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 03 20:34:14 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 清风拂面

    一药多用,非常好

    0

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总之,该研究结果表明阿托伐他汀/二甲双胍联合治疗可能会达到额外的抗动脉粥样硬化的益处,可能是通过增加巨噬细胞胆固醇流出。

JACC:低胆固醇吸收的血液透析患者或可受益于阿托伐他汀治疗

血液透析患者对胆固醇有很高的吸收率,抑制胆固醇合成的血液透析患者可能受益于阿托伐他汀治疗。 本研究测定肠道胆固醇吸收率是否有助于预测血液透析患者服用他汀类药物的有效性。 在这项德国糖尿病血透(4D)研究(German Diabetes and Dialysis study)中,收纳入了1030例参与者,随机分配为两组,阿托伐他汀20mg/日组(n = 519)或安慰剂组(n = 511)。主要

JACC:血透患者肠道胆固醇吸收水平或影响阿托伐他汀治疗效果

血液透析(以下简称血透)患者具有高的肠道胆固醇吸收水平,他们比其他患者人群从他汀治疗中的获益较少。最新一项研究表明,肠道胆固醇吸收水平可预测血透患者用阿托伐他汀减少心血管风险的有效性,低水平胆固醇吸收者似乎可从阿托伐他汀治疗中获益,而高吸收者则不从中获益。相关论文近日在线发表于《美国心脏病学会杂志》(简称JACC)。该研究旨在探讨血透患者的胆固醇吸收

JACC:肠道胆固醇吸收率低的血透患者更能获益于阿托伐他汀治疗

瑞士伯尔尼大学Silbernagel G等人研究了血透患者中,肠道胆固醇的吸收率与阿托伐他汀治疗的收益率相关性,其研究成果发表在6月份Journal of the American College of Cardiology期刊上。 背景:血液透析患者肠道胆固醇的吸收高;相对于其他他汀治疗(抑制胆固醇合成)患者而言,其他汀受益率较低。 目的:本研究旨在探讨个体胆固醇的吸收率是否会影响阿托伐他汀

JACC:胆固醇的吸收是否影响阿托伐他汀减少血液透析患者心血管疾病危险?

    背景  血液透析患者肠道胆固醇的吸收量高;和其他患者群相比,他们不能受益于他汀类药物治疗,他汀类药物可以抑制胆固醇合成。    目的  本研究旨在探讨个体胆固醇的吸收率是否会影响阿托伐他汀减少血液透析患者心血管疾病危险的有效性。    方法  研究后分析包括在德国糖尿病透析研究(4D)中的1030名参