Cell Rep:惊奇!嗜甜的人身体脂肪比更低?!

2018-04-12 小通 生物通

一项国际合作研究表明,携带FGF21基因变异的人比其他人的脂肪含量更少。这让研究人员感到吃惊,因为去年他们刚发现这种基因变异可能是一些人特别喜欢甜食的原因之一,携带这种变异的人日常比其他人摄入更多的糖。


一项国际合作研究表明,携带FGF21基因变异的人比其他人的脂肪含量更少。这让研究人员感到吃惊,因为去年他们刚发现这种基因变异可能是一些人特别喜欢甜食的原因之一,携带这种变异的人日常比其他人摄入更多的糖。

“看上去违反常识?吃糖多的人反而体内脂肪少?”课题组成员Niels Grarup教授说。“我们正在研究这种基因突变,而且试图找到它与身体其他部分之间的联系。可以说这只是饮食和糖摄入与肥胖和糖尿病风险关联的一小块拼图。”

苹果型身材与高血压

值得注意的是,该基因突变的影响并没有看上去那么积极,新研究表明,FGF21基因变异与血压升高有关,而且腰部脂肪比臀部脂肪多,就是所谓的“苹果型”身材。

这篇发表于《Cell Reports》期刊上的最新文章基于超过45万人的血液样本、饮食和遗传数据等健康信息。“几十万人参与了这项研究,结论有一定可信性,无论体脂或血压与遗传突变的关联是小还是大,我们对结果的准确性都非常有信心。我们发现在欧洲人群中,大约20%都具有这种遗传倾向,”Niels说。

潜在药物靶点

“遗传嗜甜”的发现对于未来药物开发至关重要。目前,研究人员正试图确认靶向替代FGF21基因是否可作为治疗肥胖和糖尿病的潜在途径。

“由于FGF21与嗜甜之间具有关联,除了靶向治疗肥胖和糖尿病以外,这项研究还有助于了解激素调节机制,预测激素疗效及副作用,”Niels Grarup说。

原始出处:

Timothy M. Frayling, et al.A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.Cell Reports, Vol. 23, Issue 2, p327–336 Published in issue: April 10, 2018

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1870563, encodeId=ba3a18e0563a8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Jan 02 19:34:00 CST 2019, time=2019-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960832, encodeId=66db19608322d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 03 18:34:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308568, encodeId=caf230856802, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Mon Apr 23 17:46:46 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544067, encodeId=5c58154406ea8, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Sat Apr 14 11:34:00 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305177, encodeId=ac053051e7bd, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 12 21:54:05 CST 2018, time=2018-04-12, status=1, ipAttribution=)]
    2018-07-03 维他命
  3. [GetPortalCommentsPageByObjectIdResponse(id=1870563, encodeId=ba3a18e0563a8, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Jan 02 19:34:00 CST 2019, time=2019-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960832, encodeId=66db19608322d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jul 03 18:34:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308568, encodeId=caf230856802, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Mon Apr 23 17:46:46 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544067, encodeId=5c58154406ea8, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Sat Apr 14 11:34:00 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305177, encodeId=ac053051e7bd, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 12 21:54:05 CST 2018, time=2018-04-12, status=1, ipAttribution=)]
    2018-04-23 祝您健康

    学习

    0

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    2018-04-12 天地飞扬

    了解一下.谢谢分享!

    0