Clin Infect Dis:耐药微生物导致的院内感染的危害 你需要了解!

2017-09-28 梁舒瑶 环球医学

耐药微生物给人类健康造成威胁。2017年5月,发表在《Clin Infect Dis》的一项回顾性队列研究调查了耐药微生物导致的院内感染对发病率、死亡率和住院时间的影响。

耐药微生物给人类健康造成威胁。2017年5月,发表在《Clin Infect Dis》的一项回顾性队列研究调查了耐药微生物导致的院内感染对发病率、死亡率和住院时间的影响。

背景:多药耐药菌感染(MDROs)是一大全球性的威胁,且在医院尤为常见。本研究旨在评价MDROs导致的院内感染对发病率、死亡率和住院时间的影响。

方法:该研究为一项回顾性队列研究。筛选年龄≥18岁,呼吸、尿路、血流或手术部位感染的多药耐药(病例)或多药敏感(对照)成人样本。测量指标包括医院全因死亡率(感染后总死亡率和30天死亡率)、住院时间(LOS)以及5个发病指征:入住重症监护室或手术室、感染后诊断检测的次数,以及出院后30天内再次入院或入急诊部。

结果
:该样本包括324例病例和676例对照患者。感染MDRO的患者的医院全因死亡率(风险比[HR],1.7;95%置信区间[CI],1.25~2.32)和感染后30天死亡率(HR,1.77;95% CI,1.29~2.44)较高。病例组的再入院概率较高(比值比[OR],2.17;95% CI,1.36~3.46)。耐甲氧西林金黄色葡萄球菌(OR,2.80;95% CI,1.65~4.74)和大肠杆菌耐药菌(OR,2.28;95% CI,1.32~3.96)感染患者的急诊部就诊率显着较高。MDRO感染与任何其他结局不相关。

结论:与敏感株引起的院内感染相比,MDROs引起的院内感染增加了死亡率、再入院率,且在一些病例中急症部就诊率增加。这些似乎不影响LOS,也不影响住院、重症监护、手术或诊断检测的需要。

原始出处:
Barrasa-Villar JI, Aibar-Remón C, Prieto-Andrés P, et al.Impact on morbidity, mortality and length of stay of hospital acquired infections by resistant microorganisms.Clin Infect Dis. 2017 May 2. doi: 10.1093/cid/cix411. [Epub ahead of print]

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    2017-09-28 微笑人参

    谢谢!分享.谢谢!

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