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拜耳的Stivarga未被NICE纳入肝癌的治疗

2018-02-09 MedSci MedSci原创

拜耳的Stivarga
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现在看来，肝癌患者不太可能获得拜耳的Stivarga，因为成本监管机构发布了拒绝为该药物提供资金的最终草案。美国国家健康和护理研究所（NICE）坚持不推荐这种药物用于治疗已经扩散到全身的肝癌，不可手术的，而且之前也曾使用过Stivarga这种药物的患者。Stivarga是肝癌患者的首选治疗方案，但对于那些不能耐受或无应答的患者，唯一的选择是最好的支持治疗。在这些情况下，Stivarga（regor


现在看来，肝癌患者不太可能获得拜耳的Stivarga，因为成本监管机构发布了拒绝为该药物提供资金的最终草案。

美国国家健康和护理研究所（NICE）坚持不推荐这种药物用于治疗已经扩散到全身的肝癌，不可手术的，而且之前也曾使用过Stivarga这种药物的患者。

Stivarga是肝癌患者的首选治疗方案，但对于那些不能耐受或无应答的患者，唯一的选择是最好的支持治疗。

在这些情况下，Stivarga（regorafenib）在欧洲获得许可，但是NICE的独立委员会认为证据存在不确定性，增量成本效益比（ICER）高于通常被认为是成本效益的范围 NHS资源。

该委员会认为，与最佳支持性护理相比，Stivarga的合理增量成本效益比率的范围将超过5万英镑，每QALY增加高达74，559英镑，因此超出通常认为物有所值的范围。

因此不建议这种药物用于常规用途，也被认为不适合用于癌症药物基金，因为它认为数据的不确定性和成本效益不能通过额外的数据收集来解决。

不过，该研究所指出，目前对评估的建议是与有机会上诉的顾问进行的。


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    2018-11-29 ms1779634646866130

    #Stivarga#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1710561, encodeId=fa411e1056123, content=<a href='/topic/show?id=46d8168113c' target=_blank style='color:#2F92EE;'>#Stivarga#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16811, encryptionId=46d8168113c, topicName=Stivarga)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b631868521, createdName=ms1779634646866130, createdTime=Thu Nov 29 05:03:00 CST 2018, time=2018-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289016, encodeId=978c128901664, content=<a href='/topic/show?id=077112e9237' target=_blank style='color:#2F92EE;'>#NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12792, encryptionId=077112e9237, topicName=NICE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sun Feb 11 13:03:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318471, encodeId=c52a13184e127, content=<a href='/topic/show?id=9a535625968' target=_blank style='color:#2F92EE;'>#拜耳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56259, encryptionId=9a535625968, topicName=拜耳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11b4465, createdName=ying_wu, createdTime=Sun Feb 11 13:03:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286888, encodeId=6a2f28688854, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:27:45 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286887, encodeId=511a28688e76, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:26:40 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286886, encodeId=d92328688683, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:26:37 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-02-11 fusion

    #NICE#

    0

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    2018-02-11 ying_wu

    #拜耳#

    0

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    2018-02-10 哈哈869

    学了

    0

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    2018-02-10 哈哈869

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1710561, encodeId=fa411e1056123, content=<a href='/topic/show?id=46d8168113c' target=_blank style='color:#2F92EE;'>#Stivarga#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16811, encryptionId=46d8168113c, topicName=Stivarga)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b631868521, createdName=ms1779634646866130, createdTime=Thu Nov 29 05:03:00 CST 2018, time=2018-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289016, encodeId=978c128901664, content=<a href='/topic/show?id=077112e9237' target=_blank style='color:#2F92EE;'>#NICE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12792, encryptionId=077112e9237, topicName=NICE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sun Feb 11 13:03:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1318471, encodeId=c52a13184e127, content=<a href='/topic/show?id=9a535625968' target=_blank style='color:#2F92EE;'>#拜耳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56259, encryptionId=9a535625968, topicName=拜耳)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11b4465, createdName=ying_wu, createdTime=Sun Feb 11 13:03:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286888, encodeId=6a2f28688854, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:27:45 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286887, encodeId=511a28688e76, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:26:40 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286886, encodeId=d92328688683, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Sat Feb 10 22:26:37 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-02-10 哈哈869

    学了

    0