J Endod:使用血凝块或SynOss Putty作为支架材料的牙髓再生治疗

2019-12-29 lishiting MedSci原创

SynOss Putty (Collagen Matrix, Oakland, NJ)在未发育成熟人牙齿的牙髓再生疗法(RET)中用作支架材料可以形成矿化组织。这篇研究的目的是在白鼬未发育成熟牙齿中使用并比较2种支架材料对RET疗效的影响:血凝块和SynOss Putty。

SynOss Putty (Collagen Matrix, Oakland, NJ)在未发育成熟人牙齿的牙髓再生疗法(RET)中用作支架材料可以形成矿化组织。这篇研究的目的是在白鼬未发育成熟牙齿中使用并比较2种支架材料对RET疗效的影响:血凝块和SynOss Putty。

研究将8只白鼬(95-105 days old)的32颗未发育成熟犬齿分为4组:组1, 未治疗(阳性对照, n = 8); 组2, 完整的牙髓摘除术后未施以任何治疗(阴性对照, n = 8); 组3, 采用血凝块的血管再生疗法(n = 8); 组4, 采用SynOss Putty支架材料的血管再生术(n = 8)。3月后,处死实验动物,组织学检测观察新形成的矿化组织。数据采用chi-square和Fisher exact检验进行统计学评估。

结果显示,组1呈现正常牙髓。组2牙齿未见牙髓组织。组3的牙髓组织和成牙本质细胞层消失,根管区域以骨样组织和牙骨质样组织充填。组4所有牙齿除了1颗均未见硬组织形成,并且存在根管内/尖周炎症。SynOss Putty明显与硬组织未形成以及根管内/尖周炎症的存在相关(P < .05)。

结论:采用血凝块的RET后,可在未成熟牙齿的根管内发现硬组织形成。在使用SynOss Putty支架材料的绝大多数样本中未见组织再生。

原始出处:

Alexander A, Torabinejad M, et al. Regenerative Endodontic Treatment in Immature Noninfected Ferret Teeth Using Blood Clot or SynOss Putty as Scaffolds. J Endod. 2019 Dec 16. pii: S0099-2399(19)30838-6. doi: 10.1016/j.joen.2019.10.029.

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    2020-10-01 jxrzshh
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