Diabetes Care:美国成年糖尿病患者服用他汀类药物后高甘油三酸酯血症和估计的动脉粥样硬化性心血管疾病风险

2019-10-02 xing.T MedSci原创

由此可见,五分之一(约550万)的美国糖尿病成人会发生HTG,包括接受他汀类药物治疗和LDL-C控制良好的糖尿病患者。超过四分之三的HTG的成年人有中等或较高的10年ASCVD风险。需要做出更大的努力来促进生活方式和药物手段以解决HTG。

高甘油三酸酯血症(HTG)在糖尿病患者中很常见,他汀类药物仍然是一线治疗药物。但是,在他汀类药物治疗的甘油三酸酯(TGs)升高的糖尿病患者比例及其动脉粥样硬化性心血管疾病(ASCVD)风险尚未阐明。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员量化了使用他汀类药物治疗与未使用他汀类药物治疗的美国糖尿病成年人HTG的患病率,并估计10年ASCVD风险。

在2007–2014年全国健康和营养检查调查(NHANES)中的1448名年龄在20岁及以上的美国糖尿病成年人,研究人员根据他汀类药物的使用和LDL-C水平比较了临界HTG(TG为150–199mg/dL)和HTG(TG≥200mg/dL)的患病率,并使用Logistic回归来确定HTG的危险因素。研究人员还估计了既往无ASCVD患者的10年ASCVD风险。

他汀类药物使用者的临界HTG和HTG患病率分别为20.0%和19.5%,非他汀类药物使用者分别为20.1%和25.3%(P<0.0001)。即使在LDL-C<70mg/dL的他汀类药物使用者中,临界HTG患病率为16.8%,HTG患病率为16.7%。约有77.5%的HTG患者估计的10年ASCVD风险≥7.5%,将近40%的他汀类药物使用者ASCVD风险≥20%。

由此可见,五分之一(约550万)的美国糖尿病成人会发生HTG,包括接受他汀类药物治疗和LDL-C控制良好的糖尿病患者。超过四分之三的HTG的成年人有中等或较高的10年ASCVD风险。需要做出更大的努力来促进生活方式和药物手段以解决HTG。 

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  5. 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  6. 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  7. 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    2019-10-05 thm112988

    0

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中国入选近20万人的4C研究发现,为更好地评估糖尿病、心血管疾病、癌症和死亡风险,除了检测空腹血糖和糖化血红蛋白(HbA1c)外,也应将常规检测餐后2小时血糖。

关注基层糖尿病规范化诊疗——“星火计划“中国糖尿病临床规范化诊疗促进项目河南站正式启动

为提高我国基层糖尿病防控意识和整体诊疗能力,规范糖尿病诊治和管理流程,贯彻“健康中国2030”规划纲要基层医疗体系疾病防控的目标要求。

J Clin Hypertens:随机双盲研究称:高血压伴糖尿病患者,初始应选择以培哚普利为基础的联合降压

2型糖尿病和高血压均是心血管和肾脏并发症的危险因素。两者往往会同时存在,2型糖尿病患者中高血压比普通人群更常见,估计超过50%。

四大神刊:大蒜提取物竟降低胃癌死亡率!近半获批抗癌药证据存在较高偏倚风险?

短期幽门螺杆菌治疗显著降低胃癌发病率和死亡率的风险,且持续时间最长。

20年首次突破!FDA批准卡格列净治疗“糖尿病肾病”适应症!

2019年9月30日,美国食品药品监督管理局(FDA)批准了卡格列净(怡可安®)肾病获益适应症:卡格列净用于降低糖尿病肾病患者的终末期肾病、肾功能恶化、心血管死亡以及心衰住院风险。这使卡格列净成为近20年来首个且唯一一个在糖尿病肾病患者中延缓肾病进展同时降低心衰住院风险的降糖药。