Acta Paediatr.:更高的氧饱和度可减少不良体重增加作为早产儿视网膜病变预测因子的作用!

2017-09-09 cuiguizhong MedSci原创

瑞典哥德堡大学Sahlgrenska学院神经科学和生理学研究所临床神经科学系眼科学科的Lundgren P近日在Acta Paediatr发表了他们团队近期的一项工作,他们比较了在实施更高的氧饱和度(SpO2)治疗前后出生的婴儿,研究将不良体重增加作为治疗早产儿视网膜病变(ROP)婴儿的危险因素的可行性。

瑞典哥德堡大学Sahlgrenska学院神经科学和生理学研究所临床神经科学系眼科学科的Lundgren P近日在Acta Paediatr发表了他们团队近期的一项工作,他们比较了在实施更高的氧饱和度(SpO2)治疗前后出生的婴儿,研究将不良体重增加作为治疗早产儿视网膜病变(ROP)婴儿的危险因素的可行性。

他们在瑞典哥德堡的女王西尔维亚儿童医院,对出生后31周内的婴儿。其中,2011 - 2012年期间进行早产儿视网膜病变(ROP)治疗有127例,当时的SpO2指标为88-92%;2015 - 2016年期间进行早产儿视网膜病变(ROP)治疗有142例,SpO2指标为91-95%。他们对这两种情况下新生儿出生特征、每周体重和早产儿视网膜病变治疗情况进行比较分析。同时,他们用体重、胰岛素样生长因子-1、新生儿ROP(WINROP)预测工具进行分析数据。

结果他们发现,在2011-2012年间进行早产儿视网膜病变(ROP)治疗的婴儿(12.6%),其产后体重增加明显低于未接受治疗的患者,但在2015-2016年间进行早产儿视网膜病变(ROP)治疗的婴儿(17.6%)和未接受治疗的ROP组中没有发现这一现象。 WINROP预测的灵敏度也从2011-2012年的87.5%下降到2015-2016年的48%。

因此,他们认为,在SpO2从88-92%增加到91-95%之后,出生后体重增加不再是重要的危险因素,WINROP也失去了预测需要进行早产儿视网膜病变(ROP)治疗的能力。这项工作具有重要的意义,启示人们,随着新生儿护理的发展,风险因素会发生明显改变。

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    2017-09-11 zutt
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2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242447, encodeId=420324244edc, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Sep 10 07:57:14 CST 2017, time=2017-09-10, status=1, ipAttribution=)]
    2017-09-11 makuansheng
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2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242447, encodeId=420324244edc, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Sep 10 07:57:14 CST 2017, time=2017-09-10, status=1, ipAttribution=)]
    2017-09-11 lqvr
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    2017-09-10 飛歌

    学习了很有用

    0

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我们确定了TR-ROP的有用预测因子。我们的研究结果表明,具有LCC病史和CPAP长期呼吸支持的早产儿具有发展TR-ROP的高风险。

Ophthalmic Res.:筛查早产儿视网膜病变:优化筛查方法!

法国第戎大学医院眼科Pallot C近日在Ophthalmic Res.发表了他们的一项重要工作,研究影响从早产儿早产的时间的因素和早产儿视网膜病变(ROP)检测,以优化开始筛查的时间点。

Ophthalmology:早产儿视网膜病变(ROP)新的危险因素被确定

这项研究的目的之一是确定早产儿视网膜病变(ROP)的“新”统计独立危险因素。另一个目标是评估任何新的风险因素是否可以解释治疗要求苛刻的ROP发生率的增加。来自丹麦的研究人员进行了一项回顾性,注册为基础的队列研究。这项研究的参与者为1997年至2008年出生在丹麦的早产儿(n=6490)。研究样本和31个候选的危险因素在3个国家登记册进行确定。数据被链接到一个独特的民事登记号码。31个候选的危险因素

Cell Cycle:在小鼠视网膜外植体培养中发现E2f1介导高葡萄糖引起的神经元死亡!

四川大学华西医院眼科系生物治疗国家重点实验室的 Chen D教授近日在Cell Cycle杂志发表了他们团队近期的一项重要工作,他们发现在小鼠视网膜外植体培养过程中,高葡萄糖可以引起的神经元死亡,其中E2f1是关键的调控因子。

JAMA:预防使用氟康唑不减少早产儿念珠菌病发生或死亡

侵袭性念珠菌病是早产儿迟发性感染的重要原因,临床体征往往表现细微。尽管采取抗真菌治疗,但其在早产儿中后果严重。伴随着念珠菌感染,近70%出生体重小于1000g的婴儿发生严重的神经发育障碍或死亡。既往随机安慰剂对照试验已表明,氟康唑预防性治疗可减少新生儿重症监护室(NICUs)侵袭性念珠菌病的发病率,以及念珠菌病的高疾病负担(≥15%)。 目前指南推荐包括在新生儿重症监护室中,对侵袭性念珠菌发病率较