Radiology:脑卒中患者皮层静脉未显影与动脉内治疗差强人意有关

2017-08-23 shaosai MedSci原创

将把微导管导入到血管闭塞部位(脑血栓、脑拴塞),利用溶栓药物( rt-PA 、尿激酶)进行超选择性溶栓,开通血管、通畅血流,必要时可行 球囊扩张血管成形术或放置支架达到顺性行血流再建的治疗方法。本研究为了评价颈内动脉或大脑中动脉(MCA)性脑卒中患者皮层静脉显影程度及其与动脉内治疗(IAT)的治疗受益间的关系,并将结果发表在Radiology上 。

将把微导管导入到血管闭塞部位(脑血栓、脑拴塞),利用溶栓药物( rt-PA 、尿激酶)进行超选择性溶栓,开通血管、通畅血流,必要时可行 球囊扩张血管成形术或放置支架达到顺性行血流再建的治疗方法。本研究为了评价颈内动脉或大脑中动脉(MCA)性脑卒中患者皮层静脉显影程度及其与动脉内治疗(IAT)的治疗受益间的关系,并将结果发表在Radiology上 。

本研究患者来自于荷兰急性缺血性脑卒中介入治疗的多中心随机临床研究。回顾性分析自2010.12-2014.03收治的患者入院时CTA资料。由1位神经放射学医师对Labbé静脉、蝶顶窦静脉及大脑中浅静脉的强化程度进行分级,分级如下:0,未显影;1,中度显影;2,完全显影。计算同侧半球的总评分,得到皮层静脉显影评分(COVES)。主要预后结果由90天mRS评分得出。利用有序Logistic回归评价基于皮层静脉评分的治疗效果与不同二分截断值的相关性。利用观察者间一致性检验来评价两位阅片者独立观察100例图像的一致性。

结果,共有397例患者纳入分析中。当COVES分为0和0以上两组时,皮层静脉评分与治疗效果间的交互作用具有统计学意义(P = .044)。当调整后COVES of 0 (n = 123)和COVES > 0 (n = 274)OR分别为1.0(95% CI: 0.5, 2.0)、2.2 (95% CI: 1.6, 4.1)。

本研究表明,急性MCA脑卒中患者受累大脑半球皮层静脉未显影(COVES=0)可能并未从IAT中受益,而(COVES>0)的患者表现从IAT中受益。

原始出处:

Jansen IGH, van Vuuren AB, van Zwam WH , et al,Absence of Cortical Vein Opacification Is Associated with Lack of Intra-arterial Therapy Benefit in Stroke.Radiology. 2017.DOI: 10.1148/radiol.2017162445

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    2017-11-19 fusion
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-31 QQ25ed180f

    得进一步学习和深入

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-24 明月清辉

    谢谢分享.学习了

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-24 189****1577

    值得推荐一下

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-24 刘煜

    学习了谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1720196, encodeId=367b1e201960e, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Fri May 25 09:30:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679100, encodeId=451c16e9100cd, content=<a href='/topic/show?id=7a2684e600b' target=_blank style='color:#2F92EE;'>#脑卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84760, encryptionId=7a2684e600b, topicName=脑卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Thu Aug 24 07:28:25 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236535, encodeId=84cd236535b2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Aug 24 07:10:09 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236527, encodeId=5e4423652ec2, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-24 忠诚向上

    内容丰富.值得学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1720196, encodeId=367b1e201960e, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Fri May 25 09:30:00 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679100, encodeId=451c16e9100cd, content=<a href='/topic/show?id=7a2684e600b' target=_blank style='color:#2F92EE;'>#脑卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84760, encryptionId=7a2684e600b, topicName=脑卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Thu Aug 24 07:28:25 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236535, encodeId=84cd236535b2, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Aug 24 07:10:09 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236527, encodeId=5e4423652ec2, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 1e1b8538m79(暂无匿称)

    不错的文章.值得一读

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Thu Aug 24 07:03:10 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236478, encodeId=2f682364e866, content=不错的文章.值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Aug 23 23:36:38 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236471, encodeId=00a52364e17b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 23 22:37:46 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 orangesking

    0

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