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新型电化学纳米生物传感器或可用于帕金森病的诊断

2017-12-13 MedSci MedSci原创

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帕金森病（PD）是一种严重的神经退行性疾病，其早期检测是治疗或预防该疾病进一步发展的关键所在。基于循环生物标志物miR-195的定量检测，研究人员研发了用于PD早期检测的电化学纳米生物传感器。研究将氧化石墨烯（EGO）和金纳米线（GNWs）修饰丝网印刷碳电极的表面。设计单链硫醇化探针与靶miRNA（miR-195）特异性杂交，并且使用多柔比星作为差分脉冲伏安法测量的电化学指示剂。扫描电镜成像和循环

帕金森病（PD）是一种严重的神经退行性疾病，其早期检测是治疗或预防该疾病进一步发展的关键所在。基于循环生物标志物miR-195的定量检测，研究人员研发了用于PD早期检测的电化学纳米生物传感器。

研究将氧化石墨烯（EGO）和金纳米线（GNWs）修饰丝网印刷碳电极的表面。设计单链硫醇化探针与靶miRNA（miR-195）特异性杂交，并且使用多柔比星作为差分脉冲伏安法测量的电化学指示剂。

扫描电镜成像和循环伏安实验结果证实了工作电极的修饰。纳米生物传感器的分析性能结果表明，生物传感的灵敏度高，检测限为2.9飞摩尔和动态范围为10.0-900.0飞摩尔。此外，与非特异性寡核苷酸相比，该检测器实现了靶miRNA的高选择性。人血清分析结果没有显示出对生物传感器功能的任何干扰。

基于这些结果，表明miR-195电化学纳米生物传感器可以用于PD的医学诊断。

原始出处：

Aghili Z, Nasirizadeh N, et al., A highly sensitive miR-195 nanobiosensor for early detection of Parkinson's disease. Artif Cells Nanomed Biotechnol. 2017 Dec 7:1-9. doi: 10.1080/21691401.2017.1411930.

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    2018-04-27 kksonne

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    2018-06-09 huanbaofeng

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    2018-11-14 jj000001

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    2017-12-15 mjldent

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    2017-12-15 xiaoyang_ambs

    #生物传感器#

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