Annals of Oncology:血液DNA检测预测患者癌症复发几率

2017-12-06 小通 生物通

今天《Annals of Oncology》发表了一篇文章,来自英国曼切斯特大学癌症研究所和Christie NHS基金会的研究人员鉴定出了与癌症复发有关的血液检测指标,这项新发现还能帮助医生和患者判断使用免疫治疗是否可能有效。


今天《Annals of Oncology》发表了一篇文章,来自英国曼切斯特大学癌症研究所和Christie NHS基金会的研究人员鉴定出了与癌症复发有关的血液检测指标,这项新发现还能帮助医生和患者判断使用免疫治疗是否可能有效。



研究机构的科学家们采用了161名2期和3期黑色素瘤术后患者的血样,发现BRAF和NRAS这两个基因异常与70%黑色素瘤(皮肤癌)相关。跟踪5年调查结果显示,血液中任意一种基因异常阳性的患者生存率仅为33%,而没有这种缺陷的患者的5年生存率约为65%。

同时,这两个基因其中任何一个有缺陷的话,患者在一年内复发的几率更高。
虽然黑色素瘤在中国的发病率不高,但这种癌症因生长部位所致早期较难察觉且扩散速度很快,一旦发生转移病情就变得不易控制,死亡率较高。合适的血液筛查方法更利于早期诊断和病情管理

这项研究的领导者、癌症研究UK曼切斯特研究所主任Richard Marais博士说:“一些黑色素瘤晚期患者即使经过治疗获得痊愈,肿瘤也很容易复发。在此之前,我们无法将这些更容易复发的患者区分开来。令人鼓舞的是,经过长期跟踪调查,通过DNA测试手段预测癌症复发相对比较准确。只需1管血就能帮助医生决策哪些患者可以采用免疫疗法以降低他们肿瘤的扩散风险。我们下一步准备检测一些其他癌症患者的血液样本,在接受初始治疗后这些患者通常都要进行常规血检。”

如果能在疾病发展之前,告知医生和患者未来需要面对哪些情况,就能彻底改变对抗晚期皮肤癌的游戏规则。目前来看,化验患者少量血液是一个不错的解决办法。

原始出处:

R J Lee, G Gremel, A Marshall, K A Myers, et al.Circulating tumor DNA predicts survival in patients with resected high-risk stage II/III melanoma .Annals of Oncology, mdx717,Published: 03 November 2017

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    2018-06-11 yyj072
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    2017-12-08 minlingfeng
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    2017-12-07 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1674432, encodeId=321316e443269, content=<a href='/topic/show?id=e8aa13359b1' target=_blank style='color:#2F92EE;'>#Oncology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13359, encryptionId=e8aa13359b1, topicName=Oncology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb7226973259, createdName=circumcision, createdTime=Thu Aug 23 12:48:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694039, encodeId=f459169403920, content=<a href='/topic/show?id=5847611661' target=_blank style='color:#2F92EE;'>#DNA检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6116, encryptionId=5847611661, topicName=DNA检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=333b29540979, createdName=yyj072, createdTime=Mon Jun 11 07:48:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865229, encodeId=eb3b1865229fc, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Dec 08 14:48:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425294, encodeId=d27a142529427, content=<a href='/topic/show?id=7eb6e134273' target=_blank style='color:#2F92EE;'>#癌症复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71342, encryptionId=7eb6e134273, topicName=癌症复发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fad3959854, createdName=lq0302, createdTime=Fri Dec 08 09:48:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267392, encodeId=f4b326e392c8, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Dec 07 00:37:30 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267307, encodeId=5e8726e3074c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Dec 06 19:00:41 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-06 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0