J Tissue Eng Regen Med:静磁场调节人牙髓干细胞的增殖、迁移、分化和YAP/TAZ活化

2018-11-04 MedSci MedSci原创

牙髓干细胞(DPSCs)是间充质干细胞群,具有多向潜能和高增殖。DPSCs是用于牙本质、牙髓、骨、软骨和肌肉的组织再生的有前景的工具。最近,磁性材料已经普遍应用于牙科诊所。据报道,静磁场可调节干细胞的增殖、迁移或分化。然而,静磁场是否影响DPSCs仍然是未知的。在我们的研究中,我们研究了静磁场对DPSCs增殖、迁移和分化的影响。 结果表明,静磁场重排了DPSCs的细胞骨架。1mT的静磁场增加

牙髓干细胞(DPSCs)是间充质干细胞群,具有多向潜能和高增殖。DPSCs是用于牙本质、牙髓、骨、软骨和肌肉的组织再生的有前景的工具。最近,磁性材料已经普遍应用于牙科诊所。据报道,静磁场可调节干细胞的增殖、迁移或分化。然而,静磁场是否影响DPSCs仍然是未知的。在我们的研究中,我们研究了静磁场对DPSCs增殖、迁移和分化的影响。

结果表明,静磁场重排了DPSCs的细胞骨架。1mT的静磁场增加DPSC增殖,以及几种生长因子如FGF-2,TGF-β和VEGF的基因表达。此外,静磁场通过调节MMP-1和MMP-2基因表达促进DPSCs的迁移。1 mT的静磁场还诱导DPSCs中的骨/牙齿发育和矿化。否则,静磁场将YAP/TAZ募集到细胞核,抑制YAP/TAZ的磷酸化,并上调两个YAP/TAZ调节基因CTGF和ANKRD1。细胞骨架抑制剂细胞松弛素D明显抑制YAP/TAZ的核定位。当YAP/TAZ被敲除时,静电磁场诱导的DPSCs矿化减少。

综上所述,该研究结果提供了静态磁场对DPSCs的影响,并为将来的组织再生奠定了基础。

原始出处:

Zheng L, Zhang L, et al., Static magnetic field regulates proliferation, migration, differentiation, and YAP/TAZ activation of human dental pulp stem cells. J Tissue Eng Regen Med. 2018 Oct;12(10):2029-2040. doi: 10.1002/term.2737. Epub 2018 Sep 2.

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    2019-03-09 gujh
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    2019-10-16 jxrzshh
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    2019-03-13 xuyu
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    2018-12-04 spoonycyy
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