SCI REP:神经外科危重患者术后急性肾损伤的发生率、危险因素及预后分析!

2017-06-26 xing.T MedSci原创

由此可见,神经外科危重患者发生术后AKI普遍存在,并与住院期间的不良预后相关。

近日,Scientific reports 杂志上发表了一篇研究文章,研究人员对对神经外科危重病人术后急性肾损伤(AKI)的发生率、围手术期危险因素和预后进行了调查。

在这项前瞻性的多中心队列研究中,研究人员招募了接受神经外科手术并进入神经外科重症监护病房(ICU)的成年患者。术后AKI的诊断是根据患者手术7天内的肾脏疾病改善全球预后标准来进行的。

研究人员招募了624例患者参与研究,这些参与者中发生术后AKI的患者有84例。研究人员发现术后AKI与ICU和死亡率、术后肾替代治疗、术后气管切开、术后重新气管插管增加有关。在发生了AKI的患者中,ICU总费用、增加的住院时间、ICU停留时间以及术后机械通气时间均有所延长。

多因素分析显示术后再次手术(调整后的比值比[OR]为5.70[95%可信区间为1.61-20.14])、术后血清胱抑素C浓度(调整后的OR为4.53[95%可信区间为1.98-10.39])、术中使用甘露醇(调整后的OR为1.97[95%可信区间为1.13-3.43])、术后APACHEII评分(调整后的OR为1.11[95%可信区间为1.06-1.16])、术中估计的失血量(调整后的OR为1.04[95%可信区间为1.0-1.08])是术后AKI发生的独立危险因素。

由此可见,神经外科危重患者发生术后AKI普遍存在,并与住院期间的不良预后相关。

原始出处:

Yujun Deng,et al. The Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury in Neurosurgical Critically Ill Patients.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04627-3

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    2017-06-26 清风拂面

    很好,谢谢分享

    0